Skip to main content
SpringerLink
Log in
SpringerLink
Log in

Immunotherapy and Interactions of Cytokines in the Host

  • Conference paper
Drug Delivery in Cancer Treatment II

Part of the book series: ESO Monographs ((ESO MONOGRAPHS))

  • 42 Accesses

Abstract

A successful outcome from any form of cancer treatment must depend on those features of a tumor which make it distinct in some way from the surrounding normal tissue. In surgery and radiation therapy this aspect is fulfilled by the histological and gross anatomical delineation of tumor tissue. Chemotherapy and immunotherapy are rather dependent on specific or unique features in metabolism, microstructures and on the molecular appearance of tumor cells compared to normal untransformed tissues. However, the lack of adequacy in controlling most malignant tumors demonstrates our present incapacity to define and apply this strategy. Nevertheless, modern medicine and hopefully also cancer treatment will benefit from the rapid development of molecular biology. The purpose of this presentation is to summarize briefly old and recent concepts of immune-interventions in cancer patients and discuss some aspects of continuously expanding research field of cytokines and growth factors in a way that may have a bearing on the clinical horizon.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Hericourt J and Richet CCR: hebd. Seanc. Acad. Sci 1895 (121): 567.

    Google Scholar 

  2. Ngu VA: In: Burchenal JH and Burkitt D (eds) Treatment of Burkitt’s Lymphoma. Springer, New York 1967 p 204

    Google Scholar 

  3. Nadler SH, Moore GE: Immunotherapy of malignant disease. Arch Surg 1969 (99): 376–381

    PubMed  CAS  Google Scholar 

  4. Andrews GA, Congdon CC, Edwards CL, Gengozian N, Nelson B, Vodopick H: Preliminary trials of clinical immunotherapy. Cancer Res 1967 (27): 2535–2541

    PubMed  CAS  Google Scholar 

  5. Trouillas P, Lapras C: Cellular immunotherapy of cerebral glioblastoma. A propos of 2 results. J Med Lyon 1969 (50): 1269–1291

    PubMed  CAS  Google Scholar 

  6. Yron I, Wood TA, Spiess P, Rosenberg SA: In vitro growth of murine T cells: V The isolation and growth of lymphoid cell infiltrating syngeneic solid tumors. J Immunol 1980 (125): 238–245

    PubMed  CAS  Google Scholar 

  7. Lotze MT, Grimme E, Mazumder A, Strausser JL, Rosenberg SA: In vitro growth of cytotoxic human lymphocytes, IV. Lysis of fresh and cultured autologous tumor by lymphocytes cultured in T cell growth factor (TCGF). Cancer Res 1981 (41): 4420–4425

    PubMed  CAS  Google Scholar 

  8. Grimm EA, Mazumder A, Zang HZ, Rosenberg SA: The lymphokine activated killer cell phenomenon: Lysis of NK resistant fresh solid tumor cells by IL-2 activated autologous human peripheral blood lymphocytes. J Exp Med 1982 (155): 1823–1851

    Article  PubMed  CAS  Google Scholar 

  9. Grimm EA, Ramsey KM, Mazumder A, Wilson DJ, Djeu JY, Rosenberg SA: Lymphokine activated killer cell phenomenon: II The precursor phenotype is serologically distinct from peripherals T lymphocytes, memory CTL, and NK cells. J Exp Med 1983 (157): 884–897

    Article  PubMed  CAS  Google Scholar 

  10. Rosenstein M, Yron I, Kaufman Y, Rosenberg SA: Lympokine-activated killer cells: Lysis of fresh syngeneic NK-resistant murine tumor cells by lymphocytes cultured in interleukin-2. Cancer Res 1984 (44): 1946–1953

    PubMed  CAS  Google Scholar 

  11. Mule JJ, Shu S, Schwarz SL, Rosenberg SA: Successful adoptive immunotherapy of established pulmonary metastases with lymphokine-activated killer cells and recombinant interleukin-2. Science 1984 (225): 1487

    Article  PubMed  CAS  Google Scholar 

  12. Rosenberg SA, Mulé JJ: mmunotheraphy of cancer with lymphokine-activated killer cells and recombinant interleukin-2. Surgery 1985 (98): 437–444

    PubMed  CAS  Google Scholar 

  13. Balch CM, Itoh K, Tilden AB: Cellular immune defects in patients with melanoma involving interleukin-2-activated lymphocyte cytotoxicity and a serum suppressor factor. Surgery 1985 (98): 151–157

    PubMed  CAS  Google Scholar 

  14. Grimm EA: Immunotherapy of advanced cancer. N Engl Med 1987 (316): 275–276

    Google Scholar 

  15. Lotze MT, Matory YL, Ettinghausen SE, Rayner AA, Sharow S, Seipp C, Custer M, Rosenberg SA: In vivo administration of purified human interleukin-2 II. Half life, Immunologic effects, and expansion of peripheral lymphoid cells in vivo with recombinant IL-2. J Immunol 1985 (135): 2865–2875

    PubMed  CAS  Google Scholar 

  16. Jacobs SK, Wilson DJ, Kornblith PL, Grimm E: Interleukin-2 or autologous lymphokine-activated cell treatment of malignant glioma:Phase I trial. Cancer Res 1986 (46): 2101–2104

    PubMed  CAS  Google Scholar 

  17. Besedovsky H, Del Rey A, Sorkin E, Dinarello CA: Immunoregulatory feedback between interleukin 1 and glucocorticoid hormones. Science (USA) 1986 (233): 652–654

    CAS  Google Scholar 

  18. Dinarello CA: An update on human interleukin-1: from molecular biology to clinical relevance. J Clin Immunol 1985 (5): 287–297

    Article  PubMed  CAS  Google Scholar 

  19. Roh MS, Drazenovich KA, Barbose J J, Dinarello CA, Cobb CF: Direct stimulation of the adrenal cortex by interleukin-1. Surgery 1987 (102): 140–146

    PubMed  CAS  Google Scholar 

  20. Coombes RC, Rothwell NJ, Shah P, Stock MJ: Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat. Bioscience Reports 1987 (7): 791–799

    Article  PubMed  CAS  Google Scholar 

  21. Beutler B, Cerami A: Cachectin and tumour necrosis factor as two sides of the same biological coin. Nature 1986 (320): 584–588

    Article  PubMed  CAS  Google Scholar 

  22. Tracey KJ, Lowry SF, Fahey III TJ, Albert JD, Fong Y, Hesse D, Beutler B, Manogue KR, Calvano S, Wei H, Cerami A, Shires GT: Cachectin-tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet 1987 (164): 415–422

    PubMed  CAS  Google Scholar 

  23. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B: An endotoxin induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci (USA) 1975 (72): 3666–3670

    Article  CAS  Google Scholar 

  24. Haranaki K, Carswell EA, Williamson BD, Prendegast JS, Satomi N, Old LJ: Purification, characterization and antitumour activity of nonrecombinant mouse tumour necrosis factor. Proc Natl Acad Sci (USA) 1986 (83): 3949–3953

    Article  Google Scholar 

  25. Old LJ: Tumor necrosis factor. Scientific American 1988 (25): 41–49

    Google Scholar 

  26. Nishimura T, Ohta S, Sato N, Togashi Y, Goto M, Hashimoto Y: Combination tumor-immunotherapy with recombinant tumor necrosis factor and recombinant interleukin 2 in mice. Int J Cancer 1987 (40): 255–261

    Article  PubMed  CAS  Google Scholar 

  27. Bodel P: Tumours and fever. Ann NY Acad Sci 1974 (230): 6–13

    Article  PubMed  CAS  Google Scholar 

  28. Coombes RC, Rothwell NJ, Shah P, Stock MJ: Changes in thermogenesis and brown fat activity in response to tumour necrosis factor in the rat. Bioscience Reports 1987 (7): 791–799

    Article  PubMed  CAS  Google Scholar 

  29. Baumann H, Richards C, Gauldie J: Interaction among hepatocyte-stimulating factors, interleukin-1, and glucocorticoids for regulation of acute phase plasma proteins in human hepatoma (HepG2) cells. J Immunol 1987 (139): 4122–4128

    PubMed  CAS  Google Scholar 

  30. Walther Z, May LT, Sehgal PB: Transcriptional regulation of the interferon-B2-B cell differentiation factor BSF-2-Hepatocyte-stimulating factor gene in human fibroblasts by other cytokines. J Immunol 1988 (140): 974–977

    PubMed  CAS  Google Scholar 

  31. Moldawer LL, Georgieff M, Lundholm K: Interleukin 1, tumour necrosis factor-alpha (cachectin) and the pathogenesis of cancer cachexia. Clin Physiol 1987 (7): 263–274

    Article  PubMed  CAS  Google Scholar 

  32. Havell E, Fiers W, North R J: The antitumor function of tumor necrosis factor (TNF). I. Therapeutic action of TNF against an established murine sarcoma is indirect, immunologically dependent, and limited by severe toxicity. J Exp Med 1988 (167): 1067–1085

    Article  PubMed  CAS  Google Scholar 

  33. North RJ, Havell EA: The antitumor function of tumor necrosis factor (TNF). II. Analysis of the role of endogenous TNF in endotoxin-induced hemorrhagic necrosis and regression of an established sarcoma. J Exp Med 1988 (167): 1086–1099

    Article  PubMed  CAS  Google Scholar 

  34. Waage A, Espevik T, Lamvik J: Detection of tumour necrosis factor-like cytotoxicity in serum from patients with septicaemia but not from untreated cancer patients. Scand J Immunol 1986 (24): 739–743

    Article  PubMed  CAS  Google Scholar 

  35. Balkwill F, Osborne R, Burke F, Naylor S, Talbot D, Durbin H, Tavernier J, Fiers W: Evidence for tumour necrosis factor-cachectin production in cancer. Lancet 1987 (2): 1229–1232

    Article  PubMed  CAS  Google Scholar 

  36. Tracey KJ, Lowry SF, Fahey III TJ, Albert JD, Fong Y, Hesse D, Beutler B, Manogue KR, Calvano S, Wei H, Cerami A, Shires GT: Cachectin-tumor necrosis factor induces lethal shock and stress hormone responses in the dog. Surg Gynecol Obstet 1987 (164): 415–422

    PubMed  CAS  Google Scholar 

  37. Sun XM, Hsueh W: Bowel necrosis induced by tumor necrosis factor in rats is mediated by platelet-activating factor. J Clin Invest 1988 (81): 1328–1331

    Article  PubMed  CAS  Google Scholar 

  38. Dinarello CA: Interleukin 1. Rev Infect Dis 1984 (6): 51–94

    Article  PubMed  CAS  Google Scholar 

  39. Hakim AA: Peripheral blood lymphocytes from patients with cancer lack interleukin-2 receptors. Cancer 1988 (61): 689–701

    Article  PubMed  CAS  Google Scholar 

  40. Ferrua B, Aussel C, Fehlman M: Human interleukin 2. Detection at the picomolar level by sandwich enzyme immunoassay. Journal of Immunological Methods 1987 (97): 215–220

    Article  PubMed  CAS  Google Scholar 

  41. Lee F, Yokota T, Otsuka T, Meyerson P, Villaret D, Coffman R, Mosmann T, Rennick D, Roehm N, Smith C et al: Isolation and characterization of a mouse interleukin cDNA clone that expresses B-cell stimulatory factor 1 activities and T-cell- and mast cell-stimulating activities. Proc Natl Acad Sci USA 1986 (83): 2061–2065

    Article  PubMed  CAS  Google Scholar 

  42. Hamaguchi Y, Kanakura Y, Fujita J, Takeda S, Nakano T, Tarui S, Honjo T, Kitamura Y: Interleukin 4 as an essential factor for in vitro clonal growth of murine connective tissue-type mast cells. J Exp Med 1987 (165): 268–273

    Article  PubMed  CAS  Google Scholar 

  43. Campbell HD, Tucker WQJ, Hort Y, Martinson ME, Mayo G, Clutterbuck EJ, Sanderson CJ, Young IG: Molecular cloning, nucleotide sequence, and expression of the gene encoding human eosinophil differentiation factor (interleukin 5). Proc Natl Acad Sci USA 1987 (84): 6629–6633

    Article  PubMed  CAS  Google Scholar 

  44. Koj A, Gordon AH, Gauldie J: An alternative regulatory pathway of the acute phase response: the role of fibroblast-derived interferon-beta 2. Experientia 1988 (44): 9–10

    Article  PubMed  CAS  Google Scholar 

  45. Hirano T, Yasukawa K, Harada H, Tage T, Yasuo W, Matsuda T, Kishiwamure S, Nakajima K, Koyama K, Wamatsu A, Tsunasawa S, Sakiyama F, Matsui H, Takahara Y, Taniguchi T, Kishimoto T: Complementary DNA for a novel human interleukin (BSF-2) that induces B lymphocytes to produce immunoblobulin. Nature 1986 (324): 73

    Article  PubMed  CAS  Google Scholar 

  46. Gelin J, Moldawer L, Lonnroth C, DeMan P, Svanborg-Eden C, Lowry S, Lundholm K: Appearence of hybridoma growth factor/interleukin 6 in the serum of cachectic mice bearing a methylcholantrene induced sarcoma. Submitted for publication

    Google Scholar 

  47. Goldstein D, Laszlo J: Interferon therapy in cancer: From Imaginon to Interferon. Cancer Res 1986 (46): 4315–4329

    PubMed  CAS  Google Scholar 

  48. Aderka D, Levo Y, Ramot B, Michalevicz R, Meytes D, Shaklai M, Hahn T, Holtmann H, Revel M, Wallach D: Reduced production of tumor necrosis factor by mononuclear cells in hairy cell leukemia patients and improvement following interferon therapy. Cancer 1987 (60): 2208–2212

    Article  PubMed  CAS  Google Scholar 

  49. Einat M, Resnitzky D, Kimchi A: Inhibitory effects of interferon on genes regulated by platlet-derived growth factor. Proc Natl Acad Sci USA 1985 (82): 7608–7612

    Article  PubMed  CAS  Google Scholar 

  50. Massague J: The TGF-8 family of growth factors and differentiation factors: Minireview. Cell 1987 (49): 437–438

    Article  PubMed  CAS  Google Scholar 

  51. Sclessinge J, Schreiber A, Levi A, Lax I, Liberman T, Yarden Y: Regulation of cell proliferation by epidermal growth factor. Critical Review in Biochemistry 1983 (14): 93–111

    Article  Google Scholar 

  52. Nickell KA, Halper J, Moses H: Transforming growth factors in solid human malignant neoplasms. Cancer Res 1983 (43): 1966–1971

    PubMed  CAS  Google Scholar 

  53. Kimball ES, Bohn WH, Cockley KD, Warren TC, Sherwin SA: Distinct high-performance liquid chromatography pattern of transforming growth factor activity in urine of cancer patients as compared with that of normal individuals. Cancer Res 1984 (44): 3613–3619

    PubMed  CAS  Google Scholar 

  54. Sherwin SA, Twardzik DR, Bohn WH, Cockley KC, Todaro GJ: High-molecular-weight transforming growth factor activity in the urine of patients with disseminated cancer. Cancer Res 1983 (43): 403–407

    PubMed  CAS  Google Scholar 

  55. Clark SC, Kamen R: The human hematopoietic colony-stimulating factors. Science 1987 (236): 1229–1237

    Article  PubMed  CAS  Google Scholar 

  56. Morrison SD: Control of food intake in cancer cachexia. A challenge and a tool. Pysiol Behav 1976 (17): 705–714

    Article  CAS  Google Scholar 

  57. Moldawer LL, Andersson C, Gelin J, Lundholm KG: Regulation of food intake and hepatic protein synthesis by recombinant-derived cytokines. Am J Physiol 1988 (254): 450–456

    Google Scholar 

  58. McCarthey DO, Kluger MJ, Vander AJ: Suppression of food intake during infection: is interleukin 1 involved? Amer J Clin Nutr 1985 (42): 1179–1182

    Google Scholar 

  59. Dinarello CA, Bernheim HA: Ability of human leukocytic pyrogen to stimulate brain prostaglandin synthesis in vitro. J Neurochem 1981 (37): 702–708

    Article  PubMed  CAS  Google Scholar 

  60. Giulian D, Lachman LB: Interleukin 1 stimulation of astroglial cell proliferation after brain injury. Science (USA) 1985 (228): 497–499

    CAS  Google Scholar 

  61. Houssiau FA, Bukasa K, Sindic CJM, Van Damme J, Van Snick J: Elevated levels of 26K human hybridoma growth factor (interleukin 6) in cerebrospinal fluid of patients with acute infection of the central nervous system. Clin Exp Immunol 1988 (71): 320–323

    PubMed  CAS  Google Scholar 

  62. Busbridge J, Dascombe MJ, Hoopkins S, Rothwell NJ: Acute central effects of interleukin-6 on body temperature, thermogenesis and food intake in the rat. In press 1988

    Google Scholar 

  63. Shimomura K, Manda T, Mukumoto S, Kobayashi K, Nakano K, Mori J: recombinant human tumor necrosis factor-a: Thrombus formation is a cause of anti-tumor activity. Int J Cancer 1988 (41): 243–247

    Article  PubMed  CAS  Google Scholar 

  64. Baron PL, Lawrence W Jr, Chan WMY, White FKH, Banks WL: Effects of parenteral nutrition on cell cycle kinetics of head and neck cancer. Arch Surg 1986 (121): 1282–1286

    Article  PubMed  CAS  Google Scholar 

  65. Edström S, Westin T, Delle U, Lundholm K: Cell cycle distribution and ornithine decarboxylase activity in head and neck cancer in response to enteral nutrition. Eur J Cancer Clin Oncol 1988 (in press)

    Google Scholar 

  66. Lönnroth C, Moldawer L, Gelin J, Kindblom LG, Mizel B, Lundholm G: Spontaneous interleukin-1 - alpha and cachectin production by tumor cell of cachectic tumor-bearing mice. J. Exper Med. In press 1988

    Google Scholar 

  67. Duncombe AS, Gottlieb DJ, Bianchi A, Brenner MK: Bioactivity and immunoreactivity of tumor necrosis factor in cancer patients: letter to the Editor. Lancet 1988 (Januari 30 ): 248

    Google Scholar 

  68. Oliff A, DefeoJones D, Boyer M, Martinez D, Kiefer D, Vuocolo G, Wolfe A, Socher SH: Tumors secreting human TNF-cachectin induce cachexia in mice. Cell 1987 (50): 555–563

    Article  PubMed  CAS  Google Scholar 

  69. Sherry BA, Gelin J, Fong Y, Marano M, Wei H, Cerami A, Lowry S, Lundholm K, Moldawer L: Anticachectin/tumor necrosis factor-alpha antibodies attenuate the development of cachexia in two murine transplantable tumor models. Submitted for publication 1988

    Google Scholar 

  70. Yagi MJ, Holland JF, Bekesi JG: Tumor necrosis factor enhances murine SL3-3 retrovirus replication. J Clin Lab Immunol 1987 (24): 129–134

    PubMed  CAS  Google Scholar 

  71. Kawakami M, Cerami A: Studies of endotoxin induced decrease in lipoprotein lipase activity. J Exp Med 1981 (154): 631–637

    Article  PubMed  CAS  Google Scholar 

  72. Baracos V, Rodemann HP, Dinarelk CA, Goldberg AL: Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (Interleukin 1). New Engl J Med 1983 (308): 553–558

    Article  PubMed  CAS  Google Scholar 

  73. Moldawer LL, Svaninger G, Gelin J, Lundholm K: lnterleukin-1 (alpha or beta) and tumor necrosis factor alpha do not regulate protein balance in skeletal muscle. Am J Physiol 1987 (253): C766–C773

    PubMed  CAS  Google Scholar 

  74. Goldberg AL, Kettelhut IC, Furuno K, Fagan JM, Baracos V: Activation of protein breakdown and prostaglandin E2 production in rat skeletal muscle in fever is signaled by a macrophage product distinct from interleukin 1 or other known monokines. J Clin Invest 1988 (81): 1378–1383

    Article  PubMed  CAS  Google Scholar 

  75. Hill MR, Stith RD, McCallum RE: Interleukin 1: a regulatory role in glucocorticoid regulated hepatic metabolism. J Immunol 1986 (137): 858–862

    PubMed  CAS  Google Scholar 

  76. Roh MS, Drazenovich KA, Barbose JJ, Dinarello CA, Cobb CF: Direct stimulation of the adrenal cortex by interleukin-1. Surgery 1987 (102): 140–146

    PubMed  CAS  Google Scholar 

  77. Knudsen PJ, Dinarello CA, Strom TB: Glucocorticoids inhibit transcriptional and posttranscriptional expression of interleukin 1 in U937 cells. J Immunol 1987 (139): 4129–4134

    PubMed  CAS  Google Scholar 

  78. Mandrup-Poulsen T, Bendtzen K, Dinarello CA, Nerup J: Human tumor necrosis factor potentiates human interleukin 1-mediated rat pancreatic beta- cell cytotoxicity. J Immunol 1987 (139): 4077–4082

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Sahlgrenska Hospital, University of Gothenburg, Sweden

    K. G. Lundholm

Authors
  1. K. G. Lundholm
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Surgery, Regional Hospital, 70185, Örebro, Sweden

    Lennart Domellöf

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Lundholm, K.G. (1989). Immunotherapy and Interactions of Cytokines in the Host. In: Domellöf, L. (eds) Drug Delivery in Cancer Treatment II. ESO Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74709-0_4

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74709-0_4

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74711-3

  • Online ISBN: 978-3-642-74709-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation