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ras Oncogenes in Chemical Carcinogenesis

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Oncogenes and Retroviruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 148))

Abstract

The existence of carcinogenic substances in the environment was first discovered by Percival Pott in 1775 who diagnosed the cancerous nature of the lesions in the scrotum of chimney sweeps and traced this to their continual exposure to soot. This finding was substantiated by subsequent observations of a relatively high incidence of cancer among workers in factories which used by-products of coal. We now know that such correlations have been reported not only between exposure to chemicals in the workplace and cancer, but also to exposure to radiation, viruses, and more recently, consumption of certain diets (Cairns 1981, Daudel, and Daudel 1966, Miller 1970, Wilbourn et al. 1986). The effect of many of these carcinogens, both chemical and physical, has been shown to be genetic damage, quite often by induction of point mutations or chromosomal translocations, suggesting a crucial role for gene integrity in carcinogenesis.

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  1. Dulbecco Laboratory, The Salk Institute for Biological Studies, Post Office Box 85800, San Diego, CA, 92138, USA

    Saraswati Sukumar

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  1. Saraswati Sukumar
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  1. Department of Microbiology, University of Southern California, School of Medicine, 2011 Zonal Avenue HMR-401, Los Angeles, CA, 90033-1054, USA

    Peter K. Vogt Ph. D.

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Sukumar, S. (1989). ras Oncogenes in Chemical Carcinogenesis. In: Vogt, P.K. (eds) Oncogenes and Retroviruses. Current Topics in Microbiology and Immunology, vol 148. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74700-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-74700-7_3

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