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Oncogenes pp 1-29 | Cite as

Roles of Drosophila Proto-oncogene and Growth Factor Homologs During Development of the Fly

  • F. Michael Hoffmann
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 147)

Abstract

The regulation of cell proliferation and differentiation is an essential aspect of organismal development. An important goal of investigations over the next few years will be to define the regulatory pathways of cellular proliferation and differentiation by discovering how the molecules we know about, and others that remain to be discovered, interact with one another to instruct a cell to divide or to differentiate. Growth factors, growth receptors, and the protooncogenes represent some of the components on these regulatory circuits; the challenge is to complete the “wiring-diagrams” by finding the molecular connections between the components. Molecular genetic and biochemical approaches are being applied to this problem in vertebrate cell culture and animal systems. The opportunity to use classical genetic strategies to address this problem led several groups to examine simpler organisms for the presence of proteins homologous to growth factors, growth factor receptors, or protooncogenes. It is now clear that many of these proteins have been well conserved during evolution and are found in three organisms eminently suited to genetic manipulation—yeast, Caenorhabditis elegans, and Drosophila melanogaster.

Keywords

Follicle Cell Nurse Cell Drosophila Gene Germ Band Larval Cuticle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. Michael Hoffmann
    • 1
  1. 1.McArdle Laboratory for Cancer ResearchUniversity of WisconsinMadisonUSA

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