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Capsular Polysaccharides as Vaccine Candidates

  • Conference paper
Book cover Bacterial Capsules

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 150))

Abstract

The discovery of a “specific soluble substance” secreted by pneumococci during growth (Dochez and Avery 1917) and the identification of this substance as a carbohydrate (Heidelberger and Avery 1923) were new and important developments in vaccine technology. This became evident when following the initial finding that the isolated capsular polysaccharides of pneumococci were immunogenic in mice (Schiemannand Casper 1927) it was demonstrated that they were also immunogenic in man (Francis and Tillet 1930). The potential of capsular polysaccharides as vaccines was fully confirmed when it was demonstrated unequivocally that multivalent pneumococcal polysaccharide vaccines were able to provide type-specific protection in humans against the acquisition of pneumococcal infection (MacLeod et al. 1945). However, at this time the phenomenal success of antibiotic therapy in the treatment of bacterial infections caused a lengthy hiatus in the further development of polysaccharide vaccines.

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  1. Division of Biological Sciences, National Research Council of Canada, K1A 0R6, Ottawa, Ontario, Canada

    H. J. Jennings

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  1. H. J. Jennings
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  1. Max-Planck-Institut für Immunbiologie, Stübeweg 51, 7800, Freiburg, Germany

    Klaus Jann  & Barbara Jann  & 

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Jennings, H.J. (1990). Capsular Polysaccharides as Vaccine Candidates. In: Jann, K., Jann, B. (eds) Bacterial Capsules. Current Topics in Microbiology and Immunology, vol 150. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74694-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-74694-9_6

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