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Intraoperative Radiation Therapy for Glioblastoma — Indications and Treatment Results

  • M. Matsutani
  • O. Nakamura
  • T. Nagashima
  • Y. Tanaka
  • T. Matsuda
Conference paper

Abstract

Glioma, a neoplasm of neuroectodermal origin, is oncopathologically defined as carcinoma in the brain. The most poorly differentiated glioma, glioblastoma multiforme, usually grows in the deep white matter of cerebrum and rapid invasion in multiple directions along the white matter has already occurred by the time of diagnosis. Infiltrated tumor cells into the surrounding brain tissue were observed at least 2 cm apart from the margin of the enhanced tumor area on computed tomography (CT) scan (Burger et al. 1983). In advanced stages, the tumor infiltration in the white matter extends into the contralateral hemisphere, and finally to the brain stem or the cerebellum through the cerebral peduncle. On surgery for such an invasive glioblastoma, most cases are beyond the stage for desirable removal of tumors, because of the risk of damage to the normal function of surrounding brain tissue. With surgery alone followed by best conventional care, patients have a uniformly fatal course with a median survival of 17.0 weeks (Walker et al. 1978). The restriction of the surgical treatment has inevitably required postoperative radiation therapy, which has been the most important treatment modality following surgery.

Keywords

Malignant Glioma Glioblastoma Multiforme Electron Beam Energy Isodose Line Infiltrate Tumor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Burger PC, Dubois PJ, Schold SC Jr, Smith KR Jr, Odom GL, Crafts DC, Giangaspero F (1983) Computerized tomographic and pathologic studies of the untreated, quiescent, and recurrent glioblastoma multiforme. J Neurosurg 58:159–169PubMedCrossRefGoogle Scholar
  2. Edwards MS, Levin VA, Wilson CB (1980) Brain tumor chemotherapy: an evaluation of agents in current use for phase II and III trials. Cancer Treat Rep 64:1179–1205PubMedGoogle Scholar
  3. Gutin PH, Leibel SA, Wara WM, Choucair A, Levin VA, Philips TL, Silver P, Da Silva V, Edwards MB, Davis RL, Weaver KA, Lamb S (1987) Recurrent malignant gliomas: survival following interstitial brachytherapy with high-activity iodine-125 sources. J Neurosurg 67:864–873PubMedCrossRefGoogle Scholar
  4. Hochberg FH, Pruitt A (1980) Assumption in the radiotherapy of glioblastoma. Neurology 30:907–911PubMedGoogle Scholar
  5. Matsutani M (1989) Intraoperative radiation therapy for malignant brain tumors. In: Dobelbower RR, Abe M (eds) Intraoperative radiation therapy. CRC, Boca RotanGoogle Scholar
  6. Matsutani M, Kohno T, Matsuda T, Seto T (1985) Histological evaluation of radiation therapy for glioblastoma multiforme (in Japanese). Rad System Res 2:63–69Google Scholar
  7. Matsutani M, Matsuda T, Kohno T, Asai A, Fujimaki T (1986) Intraoperative radiation therapy for glioblastoma multiforme. In: Walker MD, Thomas DGT (eds) Biology of brain tumor. Nijhoff, Boston, pp 269–275CrossRefGoogle Scholar
  8. Takakura K, Abe H, Tanaka R, Kitamura K, Miwa T, Takeuchi K, Yamamoto S, Kageyama N, Handa H, Mogami H, Nishimoto A, Uozumi T, Matsutani M, Nomura K (1986) Effects of ACNU and radiotherapy on malignant glioma. J Neurosurg 64:53–57PubMedCrossRefGoogle Scholar
  9. Salazar OM, Rubin P, Feldstein ML, Pizzutiello R (1979) High dose radiation therapy in the treatment of malignant gliomas: final report. Int J Radiat Oncol Biol Phys 5:1733–1740PubMedGoogle Scholar
  10. Walker MD, Alexander E Jr, Hunt WE, MacCarty CS, Mahaley MS Jr, Mealey J Jr, Norrell HA, Owens G, Ransohoff J, Wilson CB, Gehan EA, Strike TA (1978) Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas. A cooperative clinical trial. J Neurosurg 49: 333–343PubMedCrossRefGoogle Scholar
  11. Walker MD, Strike TA, Sheline GE (1979) An analysis of dose-effect relationship in the radiotherapy of malignant gliomas. Int J Radiat Oncol Biol Phys 5:1725–1731PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • M. Matsutani
  • O. Nakamura
  • T. Nagashima
  • Y. Tanaka
  • T. Matsuda

There are no affiliations available

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