Zusammenfassung
Die gegenwärtige Diskussion über biologische Wirkungen ionisierender Strahlen auf Zellen und Organismen schließt das Thema „Hormesis“ ein. Luckey [25] behauptet, es bestehe kein Zweifel, daß eine niedrige Strahlendosis anstatt unvermeidlichen Schaden eine allgemein „günstige“ und/oder „stimulierende“, wenn nicht sogar lebensnotwendige Reizwirkung induziert und daß sie sogar gegen höhere Dosen schützt. Aber auch eine umfassende Belegsammlung ist noch keine Theorie. Hormesis wurde bereits in einem populären Cartoon von Walt Disney „Mein Freund, das Atom“ dargestellt. Luckey [23, 24], Flemming [11], Fremlin [12], Feldmann [10] und Wachsmann [45] haben wenig mehr als Elemente aus Disneys Fantasie erläutert. Der Leser sei auf eine differenzierte Diskussion des Hormesis-Problems hingewiesen [38].
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Allan D, RH Michell: Accumulation of 1,2-diacylglycerol in the plasma membrane may lead to echinocyte transformation of erythrocytes. Nature 258, 1975: 348–349
Baisch H, H Bluhm: Effects of X-rays on cell membranes. I. Changes of membrane potential of L-cell. Rad and environm biophys 15, 1978: 213–219
Berridge MJ, RF Irvine: Inositol triophophate, a novel second messenger in cellular signal transduction. Nature 312, 1984: 315–321
Brooks RF: The transition probability model: successes, limitations and deficiencies. In: Temporal Order (eds. L. Rensing, N.I. Jaeger), Springer Berlin, Heidelberg, New York
Cairns J: The origin of human cancers. Nature 289, 1981: 353–357
Congdon CC: A review of certain low-level ionizing radiation studies in mice and guinea pigs. Health phys 52, 1987: 593–597
Fabrikant JI: Adaptation of cell renewal systems under continuous irradiation. Health phys 52, 1987: 561–570
Facchini A, NM Maraldi, S Bartoli, A Farulla, FA Manzoli: Changes in membrane receptors of B and T human lymphocytes exposed to 60Co-gamma rays. Radiat res 68, 1976: 339–348
Feinendegen LE, H Mühlensiepen, C Lindberg, J Marx, W Porschen, J Booz: Acute and temporary inhibition of thymidine kinase in mouse bone marrow cells after low-dose exposures. Int j radiat biol 45, 1984: 205–213
Feldmann A: Strahlenexposition und Strahlenwirkung. Physik in u Zt 3, 1986: 80–87
Feldmann A: Strahlenexposition und Strahlenwirkung. Physik in u Zt 1986; 4: 107–120
Flemming K: Radiopharmacology: Hazard or/and Benefit. Nukl Med 23, 1984: 87–91
Fremlin JH: Can radiation be good for us? Nucl eng 25, 1984: 103–109
Keyse SM, RM Tyrrell: Both near ultraviolet radiation and the oxidizing agent hydrogen peroxide induce a 32-kDa stress protein in normal human skin fibroblasts. J biol chem 262, 1987: 14821–14825
Köteles GJ: Radiation effects on cell membranes. Rad and environm biophys 21, 1982: 1–18
Krishnan HG, SG Pueppke: Heat shock triggers rapid protein phosphorylation in soybean seedlings. Biochem biophys res comm 148, 1987: 762–767
Kwock L, PS Lin, L Ciborowski: Differences in the effect of ionizing radiation on Na+-dependent amino acid transport in human T (Molt-4) and human B (RPMI 1788) lymphoid cells. Radiat res 80, 1979: 512–522
Lepock JR, K H Cheng, Al-Qysi, J Kruuv: Thermotropic lipid and protein transitions in Chinese hamster lung cell membranes: relationship to hyperthermic cell killing. Can j biochem cell biol 61, 1983: 421–427
Lin P S, L Kwock, K Hefter, DFH Wallach: Modification of rat thymocyte membrane properties by hyperthermia and ionizing radiation. Int j radiat biol 33, 1978: 371–382
Little JW, DW Mount: The SOS-regulatory system of Escherichia coli. Cell 29, 1982: 11–22
Low MG, AR Saltiel: Structural and functional roles of glycosyl-phosphatidylinositol in membranes. Science 239, 1988: 268–275
Lücke-Huhle C, P Herrlich: Alpha-radiation-induced amplification of integrated SV40 sequences is mediated by a trans-acting mechanism. Int j canc 39, 1987: 94–98
Lücke-Huhle C, M Pech, P Herrlich: Selective gene amplification in mammalian cells after exposure to Co60 γ-rays,241 Am α-particles or UV light. Radiat res 106, 1986: 345
Luckey TD: Hormesis with ionizing radiation. CRC Press, Boca Raton, 1979
Luckey TD: Physiological benefits from low levels of ionizing radiation. Health phys 43: 771–789
Macieira-Coelho A, C Diatloff, E Maliase: Effect of low dose rate irradiation on the division potential of cells in vitro. II. Mouse lung fibroblasts. Exp cell res 100: 228–232
Martiel JL, A Goldbeter: Autonomous chaotic behaviour of the slime mould. Nature 313, 1985: 590–592
Mitchel REJ: The arrhenius plot behavior of a γ-radiation-releasable, membrane-bound exonuclease. Radiat res 88, 1981: 426–429
Moolenaar WH, RY Tsien, PT van der Saag, SW de Laat: Na+/H+ exchange and cytoplasmic pH in the action of growth factors in human fibroblasts. Nature 304 (1983): 645–648
Moolenaar WH, LGJ Tertoolen, SW de Laat: Phorbol ester and diacylglycerol mimic growth factors in raising cytoplasmic pH. Nature 312, 1984: 371–374
Moolenaar WH, LGJ Tertoolen, SW de Laat: The regulation of cytoplasmic pH in human fibroblasts. J biol chem 259, 1984: 7563–7569
Morgen RW, MF Christman, FS Jacobson, G Storz, BN Ames: Hydrogen peroxide-inducible proteins in Salmonella typhimurium overlap with heat shock and other stress proteins. Proc nat acad sci (USA) 83, 1986: 8059–8063
Myers DK, RW Bide: Biochemical effects of X-irradiation on erythrocytes. Radiat res 27, 1966: 250–263
Nishizuka Y: Studies and perspectives of protein kinase. Science 233, 1986: 305–312
Ojeda F, M Flores, H Folch: Radiation induced loss of anti-Ig binding ability of lymphocytes. Z naturforsch 34c, 1979: 888–889
Oliviera G, J Bodycote, S Wolff: Adaptive response of human lymphcytes to low concentrations of radioactive thymidine. Science 223, 1984: 594–597
Petkau A: Effect of 22Na+ on a phospholipid membrane. Health phys 22, 1972: 239–244
Petkau A: Radiation carcinogenesis from a membrane perspective. Acta physiol scand, suppl. 492, 1980: 81–90
Radiation Hormesis. Health phys 52 (No.5) 1987
Redmann K, H L Jenssen, HJ Köhler: Experimental and functional changes in transmembrane potential and zeta potential of single cultured cells. Exp cell res 87, 1974: 281–289
Stebbing ARD, JP Norton, MD Brinsley: Dynamics of growth control in a marine yeast subjected to perturbation. J gen microbiol 130, 1984: 1799–1808
Stevenson MA, SK Calderwood, GM Hahn: Rapid increases in inositol triphosphate and intracellular Ca++ after heat shock. Biochem biophys res comm 137, 1986: 826–833
Stevenson MA, KW Minton, GM Hahn: Survival and concanavalin-A-induced capping in CHO fibroblasts after exposure to hyperthermia, ethanol and X-irradiation. Radiat res 86, 1981: 467–478
Totter JR: Physiology of the hormetic effect. Health phys 52, 1987: 549–551
Varshavsky A: Phorbol ester dramatically increases incidence of methotrexate-resistant mouse cells: possible mechanisms and relevance to tumor promotion. Cell 25, 1981: 561
Wachsmann F: Was wir über die Gefährlichkeit kleiner Strahlendosen wissen. Med tech Asstn 9, 1987: 705–707
Wagner TOF (ed) Pulsitile LHRH therapy of the male. T.M. Verlag Hameln, 1977
Wejer CJ, AJ Durston: Influence of cyclic AMP and hydrolysis products on cell type regulation in Dictyostelium discoideum. J embryl exp morph 86, 1985: 19–37
Yatvin MB: Evidence that survival of γ-irradiated Escherichia coli is influenced by membrane fluidity. Int j radiat biol 30, 1976: 571–575
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1989 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Vicker, M.G., Gerlach, H., Roebke, C., von der Heyde, F., Kimm, S.T., Gebauer, G. (1989). Hormesis und die biologische Wirkung ionisierender Strahlen: Versuche mit Lungen-Fibroblasten. In: Köhnlein, W., Traut, H., Fischer, M. (eds) Die Wirkung niedriger Strahlendosen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74676-5_23
Download citation
DOI: https://doi.org/10.1007/978-3-642-74676-5_23
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74677-2
Online ISBN: 978-3-642-74676-5
eBook Packages: Springer Book Archive