Abstract
Intra-epithelial neoplasia in the anal canal and peri-anal area has been the subject of considerable interest in recent years and the number of cases reported is increasing. Much evidence has linked anal and genital neoplasia to venereal infections, particularly human papilloma virus (HPV), and a few cases of squamous carcinoma have been reported among patients with AIDS. Symptoms may be vague or absent and the diagnosis therefore rests on careful pathological examination.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Beck DE, Fazio VW (1987) Perianal Paget’s disease. Dis Colon Rectum 30:263–266
Beck DE, Fazio VW, Jagelman DG, Lavery IC (1988) Perianal Bowen’s disease. Dis Colon Rectum 31:419–422
Beck DE, Harford FJ, Roettger RH (1989) Perianal Bowen’s disease associated with Crohn’s colitis. Report of a case. Dis Colon Rectum 32:252–255
Beckmann AM, Daling JR, McDougall JK (1985) Human papillomavirus DNA in anogenital carcinomas. J Cell Biochem 9 C:68
Bogomoletz WV, Potet F, Molas G (1985) Condylomata acuminata, giant condyloma acuminatum (Buschke-Loewenstein tumour) and verrucous squamous carcinoma of the perianal and anorectal region: a continuous precancerous spectrum? Histopathology 9:1155–1169
Choo YC, Morley GW (1980) Multiple primary neoplasms of the anogenital region. Obstet Gynecol 56:365–369
Cooper HS, Patchefsky AS, Marks G (1979) Cloacogenic carcinoma of the anorectum in homosexual men: An observation of four cases. Dis Colon Rectum 22:557–558
Croxson T, Chabon AB, Rorat E, Barash IM (1984) Intraepithelial carcinoma of the anus in homosexual men. Dis Colon Rectum 27:325–330
Daling JR, Weiss NS, Klopfenstein LL, et al. (1982) Correlates of homosexual behavior and the incidence of anal cancer. JAMA 247:1988–1990
Duggan MA, Boras VF, Inoue et al. (1989) Human papillomavirus DNA determination of anal condylomata, dysplasias, and squamous carcinomas with in situ hybridization. Am J Clin Pathol 92:16–21
Ejeckam GC, Idikio HA, Nayak V, Gardiner JP (1983) Malignant transformation in an anal condyloma acuminatum. Can J Surg 26:170–173
Fenger C (1979) The anal transitional zone. Location and extent. Acta Pathol Microbiol Scand [A]87:379–386
Fenger C (1987) The anal transitional zone (thesis). Acta Pathol Microbiol Immunol Scand [A], Suppl 289, 95:1–42
Fenger C (1988) Histology of the anal canal. Am J Surg Path 12:41–55
Fenger C (1989) Surgical pathology of the anal canal. A review of recent literature on anatomy and pathology. Progress in Surgical Pathology 10
Fenger C, Bichel P (1981) Flow cytometric DNA analysis of anal canal epithelium and anorectal tumours. Acta Pathol Microbiol Scand [A]89:351–355
Fenger C, Filipe MI (1981) Mucin histochemistry of the anal canal epithelium. Studies of normal mucosa and mucosa adjacent to carcinoma. Histochem J 13:921–930
Fenger C, Knoth M (1981) The anal transitional zone. A scanning and transmission electron microscopic investigation of the surface epithelium. Ultrastruct Pathol 2:163–173
Fenger C, Lyon H (1982) Endocrine cells and melanin-containing cells in the anal canal epithelium. Histochem J 14:631–639
Fenger C, Nielsen VT (1981) Dysplastic changes in the anal canal epithelium in minor surgical specimens. Acta Pathol Microbiol Scand [A]89:463–465
Fenger C, Nielsen VT (1986a) Precancerous changes in the anal canal epithelium in resection specimens. Acta Pathol Microbiol Immunol Scand [A] 94:63–69
Fenger C, Nielsen VT (1986b) Intraepithelial neoplasia in the anal canal. The appearance and relation to genital neoplasia. Acta Pathol Microbiol Immunol Scand [A]94:343–349
Gordon BS (1956) Unsuspected lesions in anal tissue removed for minor conditions. Arch Surg 73:741–746
Grodsky L (1967) Unsuspected anal cancer discovered after minor anorectal surgery. Dis Colon Rectum 10:471–478
Gupta J, Pilotti S, Shah KV et al. (1987) Human papillomavirus-associated early vulvar neoplasia investigated by in situ hybridization. Am J Surg Pathol 11:430–434
Howard LC, Paterson-Brown S, Weber JN et al. (1986) Squamous Carcinoma of the anus in young homosexual men with T-helper cell depletion. Genitourin Med 62:393–395
Ikenberg H, Gissmann L, Gross G et al. (1983) Human papillomavirus type-16-related DNA in genital Bowen’s disease and in Bowenoid papulosis. Int J Cancer 32:563–565
Jenkins D, Tay SK, Maddox PH (1987) Routine papillomavirus antigen staining of cervical punch biopsy specimens. J Clin Pathol 40:1212–1216
Kaplan AL, Kaufman RH, Birken RA, Simkin S (1981) Intraepithelial carcinoma of the vulva with extension to the anal canal. Obstet Gynecol 58:368–371
Leao PHS, Ferreira FV (1979) Histologic similarities between dysplasia in the anorectal junction and in the cervix uteri. Ceara Medico 1/2:8–13
Li FP, Osborn D, Cronin CM (1982) Anorectal squamous carcinoma in two homosexual men. Lancet 14:391
Löning T, Riviere A, Henke RP et al. (1988) Penile/anal condylomas and squamous cell cancer. A HPV DNA hybridization study. Virchows Archiv [A]413:491–498
Nash G, Allen W, Nash S (1986) Atypical lesions of the anal mucosa in homosexual men. JAMA 256:873–876
Nielsen OV, Jensen SL (1981) Basal cell carcinoma of the anus — a clinical study of 34 cases. Br J Surg 68:856–857
Ordonez NG, Await H, Mackay B (1987) Mammary and extramammary Paget’s disease. Cancer 59:1173–1183
Patterson JW, Kao GF, Graham JH, Helwig EB (1986) Bowenoid papulosis. A clinicopathologic study with ultrastructural observations. Cancer 57:823–836
Peters RK, Mack TM (1983) Patterns of anal carcinoma by gender and marital status in Los Angeles County. Br J Cancer 48:629–636
Peters RK, Mack TM, Bernstein L (1984) Parallels in the epidemiology of selected anogenital carcinomas. J Natl Cancer Inst 72:609–613
Pilotti S, Rilke F, Shah KV, et al. (1984) Immunohistochemical and ultrastructural evidence of papiloma virus infection associated with in situ and microinvasive squamous cell carcinoma of the vulva. Am J Surg Pathol 8:751–761
Quan SH (1980) Malignant anal and perianal tumors. Pract Gastroenterol 4:46–51
Ramos R, Salinas H, Tucker L (1983) Conservative approach to the treatment of Bowen’s disease of the anus. Dis Colon Rectum 26:712–715
Richart RM (1973) Cervical intraepithelial neoplasia. Pathol Ann 163:301–328
Rüdlinger R, Grob R, Yu YX, Schnyder UW (1989) Human papillomavirus-35-positive Bowenoid papulosis of the anogenital area and concurrent human papillomavirus-35-positive verruca with Bowenoid dysplasia of the periungual area. Arch Derm 125:655–659
Scheurlen W, Stremlau A, Gissmann L et al. (1986) Rearranged HPV 16 molecules in an anal and in a laryngeal carcinoma. Int J Cancer 38:671–676
Schlaerth JB, Morrow CP, Nalick RH, Gaddis O (1984) Anal involvement by carcinoma in situ of the perineum in women. Obstet Gynecol 64:406–411
Stacy D, Burrell MO, Franklin EW (1986) Extramammary Paget’s disease of the vulva and anus: use of intraoperative frozen-section margins. Am J Obstet Gynecol 155:519–523
Strauss RJ, Fazio VW (1979) Bowen’s disease of the anal and perianal area, a report and analysis of twelve cases. Am J Surg 137:231–234
Wells M, Robertson S, Lewis F, Dixon MF (1988) Squamous carcinoma arising in a giant perianal condyloma associated with human papillomavirus types 6 and 11. Histopathology 12:319–323
Wexner SD, Smithy WB, Milsom JW, Dailey TH (1986) The surgical management of anorectal diseases in AIDS and pré-AIDS patients. Dis Colon Rectum 29:719–723
Wexner SD, Milsom JW, Dailey TH (1987) The demographics of anal cancers are changing. Identification of a high-risk population. Dis Colon Rectum 30:942–946
Wickenden C, Malcolm ADB, Byrne M et al. (1987) Prevalence of HPV DNA and viral copy numbers in cervical scrapes from women with normal and abnormal cervices. J Pathol 153:127–135
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Fenger, C. (1990). Intra-epithelial Neoplasia in the Anal Canal and Peri-anal Area. In: Williams, G.T. (eds) Gastrointestinal Pathology. Current Topics in Pathology, vol 81. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74662-8_5
Download citation
DOI: https://doi.org/10.1007/978-3-642-74662-8_5
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74664-2
Online ISBN: 978-3-642-74662-8
eBook Packages: Springer Book Archive