Radioimmunotherapy of Solitary Liver Metastases by Means of Intratumoral Instillation of the CEA-Antibody 131 J-BW 431/26

Abstract

Radiolabelled monoclonal antibodies against tumour-associated antigens have opened up new perspectives in tumour diagnosis. As far as tumour therapy is concerned, systemic administration in human beings has been unsuccessful so far. This can be explained by a low antibody accumulation in tumour tissue. Even intra-arterially administering the antibody can be unsuccessful if perfusion of the metastasis is low. Taking these factors into account we injected radiolabeled antibodies into the tumour. The decision to proceed along these lines was strengthened by the knowledge that this approach has been shown to be capable of retarding tumour proliferation of tumour transplants on nude mice.