Central Nervous System Relapse Prevention in 1165 Standard-Risk Children with Acute Lymphoblastic Leukemia in Five BFM Trials

  • C. Bührer
  • G. Henze
  • J. Hofmann
  • A. Reiter
  • G. Schellong
  • H. Riehm
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

In children with acute lymphoblastic leukemia (ALL), relapse in the CNS is still a major limiting factor for cure [1]. CNS relapse prevention by cranial irradiation plus intrathecal methotrexate [2], while adequately protective for most patients, is stigmatized by considerable neurological and other sequelae [3]. For standard-risk ALL children (60% of all patients), the BFM study group has addressed the necessity of cranial irradiation in a risk-adapted and randomized fashion in trials ALL-BFM 81 and 83. Together with the historical controls of the preceding trials ALL-BFM 70, 76, and 79, the overall as well as the CNS relapse incidence in these trials is presented here.

Keywords

Lymphoma Leukemia Oncol Methotrexate Nial 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • C. Bührer
    • 1
  • G. Henze
    • 2
  • J. Hofmann
    • 1
  • A. Reiter
    • 1
  • G. Schellong
    • 3
  • H. Riehm
    • 1
  1. 1.Departments of PediatricsHannover Medical SchoolGermany
  2. 2.Free University of BerlinGermany
  3. 3.Münster UniversityGermany

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