Intensive Chemotherapy for Acute Lymphoblastic Leukaemia in Adults
High-dose cytosine arabinoside (HD Ara-C) has been shown to induce complete remission in acute lymphoblastic leukaemia (ALL) which is refractory to, or which has recurred following conventional therapy [1–5]. This study was undertaken to determine whether the incorporation of HD Ara-C at a dose of 2 g/m2 twice daily for 6 days into the treatment previously used at St. Bartholomew’s Hospital (OPAL)  would improve the prognosis of adults with ALL.
KeywordsToxicity Filtration Lymphoma Leukemia Oncol
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- 5.de Marsh RW, Wozniak A, McCarley D (1987) Therapy of relapsed acute lymphoblastic leukaemia: a 5 year experience with high dose ara-C. Proc Am Assoc Cancer Res Am Soc Clin Oncol 6:147 (in Proc Am Soc Cl in Oncol)Google Scholar
- 6.Lister TA, Whitehouse JMA, Beard MEJ et al. (1978) Combination chemotherapy for acute lymphoblastic leukaemia in adults. Br Med J: 199–203Google Scholar
- 7.Barnett MJ, Greaves MF, Amess JAL et al. (1976) Treatment of acute lymphoblastic leukaemia in adults. Br J Haematol 33: 455–468Google Scholar
- 12.Cox DR (1972) Regression models and lifetables. R Stat Soc [B] 34: 187–220Google Scholar