Acute Megakaryoblastic Leukemia (FAB-M7) in an Infant Presenting with Orbital Chloroma and Meningeal Involvement

  • M. Suttorp
  • H. Polchau
  • B. Kühn
  • H. Löffler
  • M. Rister
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)


Although described as early as 50 years ago [20], acute leukemia of megakaryocytic lineage (AMegL) was only recently added to the French-American-British (FAB) classification as FAB-M7 [2, 3]. To establish the diagnosis for this category, sophisticated techniques like ultrastructural cytochemistry or immunological techniques are required. The limited data available suggest a frequency of 3%-12% in adult acute nonlymphoblastic leukemia (ANLL) [15]. In childhood only 20 cases with a definitive diagnosis of AMegL hade been reported up to the year 1986 [5]. To the best of our knowledge the present case is the first in which cranial chloroma was associated with AMegL.


Acute Myeloid Leukemia Acute Leukemia Blast Cell Granulocytic Sarcoma Megakaryoblastic Leukemia 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. Suttorp
    • 1
  • H. Polchau
    • 1
  • B. Kühn
    • 1
  • H. Löffler
    • 2
  • M. Rister
    • 1
  1. 1.Dept. of PediatricsUniversity of KielGermany
  2. 2.Dept. of Internal MedicineUniversity of KielGermany

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