Acute Megakaryoblastic Leukemia (FAB-M7) in an Infant Presenting with Orbital Chloroma and Meningeal Involvement

  • M. Suttorp
  • H. Polchau
  • B. Kühn
  • H. Löffler
  • M. Rister
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

Although described as early as 50 years ago [20], acute leukemia of megakaryocytic lineage (AMegL) was only recently added to the French-American-British (FAB) classification as FAB-M7 [2, 3]. To establish the diagnosis for this category, sophisticated techniques like ultrastructural cytochemistry or immunological techniques are required. The limited data available suggest a frequency of 3%-12% in adult acute nonlymphoblastic leukemia (ANLL) [15]. In childhood only 20 cases with a definitive diagnosis of AMegL hade been reported up to the year 1986 [5]. To the best of our knowledge the present case is the first in which cranial chloroma was associated with AMegL.

Keywords

Lactate Leukemia Aldehyde Anemia Oncol 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Bain BJ, Catovsky D, O’Brien M (1981) Megakaryoblastic leukemia presenting as acute myelofibrosis: a study of 4 cases with the platelet peroxidase reaction. Blood 58: 206–213PubMedGoogle Scholar
  2. 2.
    Bennet JM, Catovsky D, Daniel MT (1985) Criteria for the diagnosis of acute leukemia of megakaryocyte lineage ( M7 ). Ann Intern Med 103: 460–462Google Scholar
  3. 3.
    Bennet JM, Catovsky D, Daniel MT (1985) Proposed revised criteria for the classification of acute myeloid leukemia. Ann Intern Med 103: 620–625Google Scholar
  4. 4.
    Breton-Gorius J, Reyes F, Duhamel G (1978) Megakaryoblastic acute leukemia: identification by the ultrastructural demonstration of platelet peroxidase. Blood 51: 45–60PubMedGoogle Scholar
  5. 5.
    Cairney AEL, McKenna R, Arthur DC (1986) Acute megakaryoblastic leukaemia in children. Br J Haematol 63: 541–554PubMedCrossRefGoogle Scholar
  6. 6.
    Chan WC, Byrnes RK, Kim TH (1983) Acute megakaryoblastic leukemia in early childhood. Blood 62: 92–98PubMedGoogle Scholar
  7. 7.
    Choi S, Simone JV (1976) Acute nonlymphocytic leukemia in 171 children. Med Pediatr Oncol 2: 119–227PubMedCrossRefGoogle Scholar
  8. 8.
    Den-Ottolander GJ, TeVelde J, Brederoo P (1979) Megakaryoblastic leukaemia (acute myelofibrosis): a report of three cases. Br J Haematol 42: 9 - 20PubMedCrossRefGoogle Scholar
  9. 9.
    Huang MJ, Li CY, Nichols WL (1984) Acute leukemia with megakaryocytic differentiations: a study of 12 cases identified immunocytochemically. Blood 64: 427–439PubMedGoogle Scholar
  10. 10.
    Koike T (1984) Megakaryoblastic leukemia: the characterization and identification of megakaryoblasts. Blood 64: –-692Google Scholar
  11. 11.
    Koike T, Aoki S, Maruyama S (1987) Cell surface phenotyping of megakaryoblasts. Blood 89: 957–960Google Scholar
  12. 12.
    Krause JR (1979) Granulocytic sarcoma preceding acute leukemia. Cancer 44: 1017–1020PubMedCrossRefGoogle Scholar
  13. 13.
    Lampkin BC, Lange B, Bernstein I (1988) Biologic characteristics and treatment of acute nonlymphocytic leukemia in children. Pediatr Clin North Am 35: 743–764PubMedGoogle Scholar
  14. 14.
    Nowell PC, Finan JB (1978) Cytogenetics of acute and chronic myelofibrosis. Virchows Arch [B] 29: 45–50Google Scholar
  15. 15.
    Peterson BA, Levine EG (1987) Uncommon subtypes of acute nonlymphocytic leukemia: clinical features and management of FAB M5, M6, M7. Semin Oncol 14: 425–434Google Scholar
  16. 16.
    Pui CH, William DL, Scarborough V (1982) Acute megakaryoblastic leukaemia associated with intrinsic platelet dysfunction and constitutional ring 21 chromosome in a young boy. Br J Haematol 50: 191–200PubMedCrossRefGoogle Scholar
  17. 17.
    Pui CH, Dahl GV, Kalwinsky DK (1985)Central nervous system leukemia in children with acute nonlymphoblastic leukemia. Blood 66: 1062–1067Google Scholar
  18. 18.
    Ruiz-Arguelles G J, Marin-Lopez A, Lobato-Mendizabal E (1986) Acute megakaryoblastic leukaemia: a prospective study of its identification and treatment. Br J Haematol 62: 55–63PubMedCrossRefGoogle Scholar
  19. 19.
    Sariban E, Oliver E, Corash L (1984) Acute megakaryoblastic leukemia in childhood. Cancer 54: 1423–1428PubMedCrossRefGoogle Scholar
  20. 20.
    Van Boros J, Karenyi A (1931) Über einen Fall von akuter Megakaryoblastenleukämie, zugleich einige Bemerkungen zum Problem der akuten Leukämie. Z Klin Med 118: 697–718Google Scholar
  21. 21.
    Zipursley A, Peeters M, Poon A (1987) Megakaryoblastic leukemia and Down’s syndrome: a review. Pediatr Hematol Oncol 4: 211–216Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • M. Suttorp
    • 1
  • H. Polchau
    • 1
  • B. Kühn
    • 1
  • H. Löffler
    • 2
  • M. Rister
    • 1
  1. 1.Dept. of PediatricsUniversity of KielGermany
  2. 2.Dept. of Internal MedicineUniversity of KielGermany

Personalised recommendations