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Acute Leukemias II pp 368–373Cite as

Acute Megakaryoblastic Leukemia (FAB-M7) in an Infant Presenting with Orbital Chloroma and Meningeal Involvement

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Part of the book series: Haematology and Blood Transfusion / Hämatologie und Bluttransfusion ((HAEMATOLOGY,volume 33))

Abstract

Although described as early as 50 years ago [20], acute leukemia of megakaryocytic lineage (AMegL) was only recently added to the French-American-British (FAB) classification as FAB-M7 [2, 3]. To establish the diagnosis for this category, sophisticated techniques like ultrastructural cytochemistry or immunological techniques are required. The limited data available suggest a frequency of 3%-12% in adult acute nonlymphoblastic leukemia (ANLL) [15]. In childhood only 20 cases with a definitive diagnosis of AMegL hade been reported up to the year 1986 [5]. To the best of our knowledge the present case is the first in which cranial chloroma was associated with AMegL.

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Author information

Authors and Affiliations

  1. Dept. of Pediatrics, University of Kiel, Germany

    M. Suttorp, H. Polchau, B. Kühn & M. Rister

  2. Dept. of Internal Medicine, University of Kiel, Germany

    H. Löffler

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  1. M. Suttorp
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  2. H. Polchau
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  3. B. Kühn
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  4. H. Löffler
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  5. M. Rister
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Editor information

Editors and Affiliations

  1. Departments of Internal Medicine and Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, D-4400, Münster, Federal Republic of Germany

    T. Büchner , G. Schellong , W. Hiddemann  & J. Ritter , ,  & 

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© 1990 Springer-Verlag Berlin Heidelberg

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Suttorp, M., Polchau, H., Kühn, B., Löffler, H., Rister, M. (1990). Acute Megakaryoblastic Leukemia (FAB-M7) in an Infant Presenting with Orbital Chloroma and Meningeal Involvement. In: Büchner, T., Schellong, G., Hiddemann, W., Ritter, J. (eds) Acute Leukemias II. Haematology and Blood Transfusion / Hämatologie und Bluttransfusion, vol 33. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74643-7_70

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  • DOI: https://doi.org/10.1007/978-3-642-74643-7_70

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-50984-4

  • Online ISBN: 978-3-642-74643-7

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