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Therapy of Childhood Acute Myelogenous Leukemia: An Update of the AIEOP/LAM 8204 Study

  • S. Amadori
  • A. Ceci
  • A. Comelli
  • E. Madon
  • G. Masera
  • L. Nespoli
  • G. Paolucci
  • L. Zanesco
  • M. L. Vegna
  • M. L. Moleti
  • A. M. Testi
  • F. Mandelli
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

Over the past decade there have been significant advances in the treatment of acute myelogenous leukemia (AML). The introduction of intensive induction and post-remission chemotherapy programs, together with the improvement in supportive care, have resulted in a probability of long-term survival in 30%–50% of children with AML [1–4]. In 1982 the AIEOP (Italian Pediatric Hematology-Oncology Association) cooperative group began a multicenter prospective trial for pediatric AML in order to establish the value of a polychemotherapeutic regimen consisting of intensive induction followed by intensive consolidation and continuation chemotherapy.

Keywords

Bone Marrow Transplant Acute Leukemia Acute Myelogenous Leukemia Cytosine Arabinoside Postremission Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Creutzig U, Ritter J, Riehm H et al. (1985) Improved treatment results in childhood acute myelogenous leukemia: a report of the German Cooperative Study AML-BFM-78. Blood 65: 298–304PubMedGoogle Scholar
  2. 2.
    Weinstein HJ, Mayer RJ, Rosenthal DS et al. (1983) Chemotherapy for acute leukemia in children and adults: VAPA update. Blood 62: 315–319PubMedGoogle Scholar
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    Gale RP, Foon KA (1987) Therapy of acute myelogenous leukemia. Semin Hematol 24: 40–54PubMedGoogle Scholar
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    Kalwinsky D, Mirro J, Schell M et al. (1988) Early intensification of chemotherapy for childhood acute non-lymphoblastic leukemia: improved remission induction with a five drug regimen including Etoposide. J Clin Oncol 6: 1134–1143PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • S. Amadori
    • 1
  • A. Ceci
  • A. Comelli
  • E. Madon
  • G. Masera
  • L. Nespoli
  • G. Paolucci
  • L. Zanesco
  • M. L. Vegna
  • M. L. Moleti
  • A. M. Testi
  • F. Mandelli
  1. 1.Institute of HematologyUniversity La SapienzaRomeItaly

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