Prognosis and DNA Aneuploidy in Children with Acute Lymphoblastic Leukemia
Childhood acute lymphoblastic leukemia (ALL) is a heterogeneous disease with respect to immunophenotype and karyotype of the blast cells, and so the biological features of the cells appear to have a strong influence on the prognosis. DNA analysis by flow cytometry (FCM) is an ideal way to detect abnormal DNA content of the leukemic cells (DNA aneuploidy), since it rapidly provides a DNA index (DI) that is independent of the mitotic index and is reliably correlated with the karyotype for DNA aneuploidy . Although a favorable outcome for patients with aneuploidy has been commonly reported from our  and other working groups [3–5], there are some apparent differences in the prognostic value among the results of each group. In the present study we report the independent prognostic significance of the cellular DNA content in high-risk children who were stratified by WBC count and age at time of diagnosis.
KeywordsLeukemia Oncol Iodide
Unable to display preview. Download preview PDF.
- 7.Wörmann B, Hiddemann W, Ritter J, Henze G, Langermann HJ, Kaufmann U, Schellong G, Riehm H, Buchner T (1985) Incidence and prognostic significance of DNA aneuploidy in childhood acute lymphoblastic leukemia. In:Buchner T, Bloomfield CD, Hiddemann W, Hossfeld DK, Schumann J (eds) Tumor aneuploidy. Springer, Berlin Heidelberg New York, pp 53–61Google Scholar