Advertisement

Prognostic Significance of Chromosome Analysis in De Novo Acute Myeloid Leukemia

  • H. J. Weh
  • R. Hoffmann
  • S. Suciu
  • J. Ritter
  • R. Kuse
  • D. K. Hossfeld
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

Since the first report by Sakurai and Sand-berg [1] in 1973, indicating a better prognosis for patients with a normal karyotype (NN) or a mixture of normal and abnormal mitoses (AN) than for patients with only abnormal mitoses (AA), several other large cytogenetic studies [2–4] have confirmed these prognostic findings in patients with de novo acute myeloid leukemia (AML). But there are also some reports denying such a prognostic value of the chromosomal status NN, AN, AA [5–7] and in more recent studies [8–10] the prognostic value of the types of chromosomal aberrations rather than the NN-AN-AA classification has been emphasized.

Keywords

Acute Myeloid Leukemia Complete Remission Acute Leukemia Complete Remission Rate Acute Nonlymphocytic Leukemia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Sakurai M, Sandberg AA (1973) Prognosis of acute myeloblastic leukemia:chromosomal correlation. Blood 41:93–104PubMedGoogle Scholar
  2. 2.
    Larson RA, Le Beau MM, Vardiman JW, Testa JR, Golomb HM, Rowley JD (1983) The predictive value of initial cytogenetic studies in 148 adults with acute nonlymphocytic leukemia:a 12-year study (1970–1982). Cancer Genet Cytogenet 10:219–236PubMedCrossRefGoogle Scholar
  3. 3.
    Fourth International Workshop on Chromo-somes in Leukemia, 1982 (1984) Clinical significance of chromosomal abnormalities in acute nonlymphoblastic leukemia. Cancer Genet Cytogenet 11:332–350Google Scholar
  4. 4.
    Berger R, Bernheim A, Ochoa-Noguera ME, Daniel MT, Valensi F, Sigaux F, Flandrin G, Boiron M (1987) Prognostic significance of chromosomal abnormalities in acute non-lymphocytic leukemia:a study of 343 patients. Cancer Genet Cytogenet 28:293–299PubMedCrossRefGoogle Scholar
  5. 5.
    Michaux JL, van den Berghe H (1982) Correlation of clinical and cytogenetic parameters in 203 adult patients with ANLL. In:3rd International symposium on therapy of acute leukemias, Rome, 11–14 Dec 1982Google Scholar
  6. 6.
    Brodeur GM, Williams DL, Kalwinsky DK, Williams KJ, Dahl GV (1983) Cytogenetic features of acute nonlymphoblastic leukemia in 73 children and adolescents. Cancer Genet Cytogenet 8:93–105PubMedCrossRefGoogle Scholar
  7. 7.
    Li YS, Hayhoe FGJ (1983) Correlation between chromosomal pattern, cytological subtypes, response to therapy, and survival in acute myeloid leukaemia. Scand J Haematol 30:265–277PubMedCrossRefGoogle Scholar
  8. 8.
    Yunis JJ, Brunning RD, Howe RB, Lobell M (1984) High resolution chromosomes as an independent prognostic indicator in adult acute nonlymphocytic leukemia. N Engl J Med 311:812–818PubMedCrossRefGoogle Scholar
  9. 9.
    Keating MJ, Cork A, Broach Y, Smith T, Walters RS, McCredie KB, Trujillo J, Freireich EJ (1987) Toward a clinically relevant cytogenetic classification of acute myelogenous leukemia. Leuk Res 11:119–133PubMedCrossRefGoogle Scholar
  10. 10.
    Misawa S, Yashige H, Horiike S, Taniwaki M, Nishigaki H, Okuda T et al. (1988) Detection of karyotypic abnormalities in most patients with acute nonlymphocytic leukemia by adding ethidium bromide to short-term cultures. Leuk Res 12:719–729PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • H. J. Weh
    • 1
  • R. Hoffmann
    • 2
  • S. Suciu
    • 1
  • J. Ritter
    • 3
  • R. Kuse
    • 2
  • D. K. Hossfeld
    • 1
  1. 1.Department of Internal Medicine, Oncology and HematologyUniversity of HamburgGermany
  2. 2.Department of Hematology AK St. GeorgHamburgGermany
  3. 3.Department of Pediatrics, Oncology and HematologyUniversity of MünsterGermany

Personalised recommendations