Prognostic Significance of Chromosome Analysis in De Novo Acute Myeloid Leukemia
Since the first report by Sakurai and Sand-berg  in 1973, indicating a better prognosis for patients with a normal karyotype (NN) or a mixture of normal and abnormal mitoses (AN) than for patients with only abnormal mitoses (AA), several other large cytogenetic studies [2–4] have confirmed these prognostic findings in patients with de novo acute myeloid leukemia (AML). But there are also some reports denying such a prognostic value of the chromosomal status NN, AN, AA [5–7] and in more recent studies [8–10] the prognostic value of the types of chromosomal aberrations rather than the NN-AN-AA classification has been emphasized.
KeywordsLeukemia Bromide Ethidium
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