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Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia:Augmentation of LAK-Cell Cytotoxicity by Combinations of Lymphokines or Cytokines

  • J. V. Teichmann
  • W. D. Ludwig
  • H. Seibt-Jung
  • E. Thiel
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

Adoptive immunotherapy with lymphokine-activated killer (LAK) cells and interleukin-2 (IL-2) or induction of cytotoxic mechanisms by IL-2 alone was shown to be a promising approach in cancer therapy [1–11]. Most of the available data come from experimental and clinical studies of solid tumors, while only little is known about the effect of LAK cells against human leukemia [12–14]. Leukemia patients have been reported to have a deficiency in natural killer (NK) cell functions which may contribute to leukemogenesis. Experimental data on correcting this deficiency by IL-2 make it possible that adoptive immunotherapy of leukemia patients may be of great value in the treatment of human leukemia [15, 16]. In the present study we investigated the ability of LAK cells to lyse fresh human leukemia cells in vitro and evaluated the augmentation of cytotoxic mechanisms by combined application of IL-2 and other lymphokines or cytokines and by inhibition of prostaglandin synthesis during the activation process.

Keywords

Hairy Cell Leukemia Adoptive Immunotherapy Prolymphocytic Leukemia Fresh Leukemic Cell Fresh Human Leukemia Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. V. Teichmann
    • 1
  • W. D. Ludwig
    • 1
  • H. Seibt-Jung
    • 1
  • E. Thiel
    • 1
  1. 1.Dept. of Hematology and Oncology, University-hospital SteglitzFree University of BerlinGermany

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