Advertisement

Allogeneic and Autologous Bone Marrow Transplantation in Acute Leukemia: The Essen Experience

  • U. W. Schaefer
  • D. W. Beelen
  • U. Graeven
  • M. Kölbel
  • H. Sayer
  • K. Quabeck
  • R. Becher
  • B. Kremens
  • B. Stollmann
  • H. Grosse-Wilde
  • M. Molls
  • U. Quast
  • D. Szy
  • E. Haralambie
  • R. Ansorg
  • O. Thraenhart
  • W. Luboldt
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)

Abstract

Chemo-/radiotherapy followed by bone marrow transplantation from sibling donors has been used successfully in many centers to treat patients with leukemia in whom primary chemotherapy failed or who were at high risk for relapses after therapy. However, only 30%–40% of patients have a matched allogeneic marrow donor. Therefore several groups initiated programs of autologous bone marrow transplantation with or without attempts to remove residual leukemic cells from the transplant by in vitro purging methods.

Keywords

Acute Lymphoblastic Leukemia Bone Marrow Transplantation Acute Leukemia Interstitial Pneumonia Total Body Irradiation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Schaefer UW (1985) Preservation of bone mar-row for transplantation. In: van Bekkum D, Löwenberg B (eds) Bone marrow transplantation. Dekker, New York, pp 513–538Google Scholar
  2. 2.
    Molls M, Bamberg M, Beelen DW, Mahmoud HK, Quast U, Schaefer UW (1987) Different TBI procedures in Essen: results and clinical considerations on the risk of leukemic relapse and interstitial pneumonitis. Strahlenther Onkol 163: 237–240Google Scholar
  3. 3.
    Mahmoud HK, Schaefer UW, Schüning F, Schmidt CG, Bamberg M, Haralambie E, Linzenmeier G, Hantschke D, Grosse-Wilde H, Luboldt W, Richter HJ (1984) Laminar air flow versus barrier nursing in marrow transplant recipients. Blut 49: 375–381PubMedCrossRefGoogle Scholar
  4. 4.
    Storb R, Epstein RB, Graham TC, Thomas ED (1970) Methotrexate regimens for control of graft-versus-host disease in dogs with allogeneic marrow grafts. Transplantation 9: 240–246PubMedCrossRefGoogle Scholar
  5. 5.
    Storb R, Deeg HJ, Whitehead J, Appelbaum F, Beatty P, Bensinger W, Buckner CD, Clift R, Doney K, Farewell V, Hansen J, Hill R, Lum L, Martin P, McGuffin R, Sanders J, Stewart P, Sullivan K, Witherspoon R, Yee G, Thomas ED (1986) Methotrexate and cyclosporine compared with cyclosporine alone for porphylaxis of acute graft versus host disease after marrow transplantation for leukemia. N Engl J Med 314: 729–735PubMedCrossRefGoogle Scholar
  6. 6.
    Beelen DW, Graeven U, Schulz G, Grosse- Wilde H, Doxiadis I, Schaefer UW, Quabeck K, Sayer H, Schmidt CG (1988) Treatment of acute graft-versus-host disease after HLA-partially matched marrow transplantation with a monoclonal antibody (BMA031) against the T cell receptor. First results of a phase-I/II trial. Onkologie 11: 56–58Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • U. W. Schaefer
    • 1
  • D. W. Beelen
    • 1
  • U. Graeven
    • 1
  • M. Kölbel
    • 1
  • H. Sayer
    • 1
  • K. Quabeck
    • 1
  • R. Becher
    • 1
  • B. Kremens
    • 1
  • B. Stollmann
    • 1
  • H. Grosse-Wilde
    • 1
  • M. Molls
    • 1
  • U. Quast
    • 1
  • D. Szy
    • 1
  • E. Haralambie
    • 1
  • R. Ansorg
    • 1
  • O. Thraenhart
    • 1
  • W. Luboldt
    • 1
  1. 1.Department of Bone Marrow TransplantationUniversity Hospital EssenGermany

Personalised recommendations