Allogeneic and Autologous Bone Marrow Transplantation in Acute Leukemia: The Essen Experience
Chemo-/radiotherapy followed by bone marrow transplantation from sibling donors has been used successfully in many centers to treat patients with leukemia in whom primary chemotherapy failed or who were at high risk for relapses after therapy. However, only 30%–40% of patients have a matched allogeneic marrow donor. Therefore several groups initiated programs of autologous bone marrow transplantation with or without attempts to remove residual leukemic cells from the transplant by in vitro purging methods.
KeywordsAcute Lymphoblastic Leukemia Bone Marrow Transplantation Acute Leukemia Interstitial Pneumonia Total Body Irradiation
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