Osteoporosis in Children with Leukemia: A Potentially Debilitating Anomaly?

  • J. A. Leeuw
  • D. A. Piers
  • W. A. Kamps
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 33)


Osteoporosis in children with leukemia can affect quality of life if it is not recognized in time. Only few reports have addressed this problem so far. Roentgenological alterations in the skeleton of children with acute lymphoblastic leukemia (ALL), compatible with loss of bone mass, can be found at diagnosis [1]. Some children even have collapsed vertebrae before leukemia treatment has been started. At least two major components of ALL treatment can cause further loss of bone mass: corticosteroids [2] and methotrexate [3]. The role of other chemotherapeutic agents is less clear. From 1987 we have estimated the presence of osteoporotic changes, studying bone mineral content in children with ALL.


Acute Lymphoblastic Leukemia Bone Mineral Content Acute Leukemia Pediatric Oncology Mediastinal Mass 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Thomas LB, Forkner CE, Frei E, Besse BE, Stabenau JR (1961) The skeletal lesions of acute leukemia. Cancer 14: 608–621PubMedCrossRefGoogle Scholar
  2. 2.
    Hahn TJ (1980) Drug induced disorders of vitamin D and mineral metabolism. Clin Endocrinol Metab 9: 107–129PubMedCrossRefGoogle Scholar
  3. 3.
    Ragab AH, Freeh RS, Vietti TJ (1970) Osteoporotic fractures secondary to methotrexate therapy of acute leukemia in remission. Cancer 25: 580–585PubMedCrossRefGoogle Scholar
  4. 4.
    Cameron JR, Sorenson J A (1963) Measurement of bone mineral in vivo: an improved method. Science 142: 230–232PubMedCrossRefGoogle Scholar
  5. 5.
    Cohn SH, Ellis KJ (1975) Predicting radial bone mineral content in normal subjects. Int J Nucl Med Biol 2: 53–57PubMedCrossRefGoogle Scholar
  6. 6.
    Benoit Y, Delbeke MJ, Eggesbo S (1981) Skeletafwijkingen bij kinderen met acute lymfoblastenleukemie. Tijdschr Kindergeneeskd 49: 153–159PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1990

Authors and Affiliations

  • J. A. Leeuw
    • 1
  • D. A. Piers
    • 2
  • W. A. Kamps
    • 1
  1. 1.Pediatric Oncology CenterUniversity HospitalGroningenThe Netherlands
  2. 2.Department of Nuclear MedicineUniversity HospitalGroningenThe Netherlands

Personalised recommendations