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Mechanisms in the Transformation of IL3-Dependent Hematopoietic Stem Cells

  • Conference paper
Mechanisms in Myeloid Tumorigenesis 1988

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 149))

Abstract

The hematopoietic system is derived from the progeny of pluripotential stem cells which can differentiate along lymphoid or myeloid lineages (Keller et al.1985; Williams et al.1984; Joyner et al.1983; Lemischka et al.1986). Interleukin 3 (IL3) is a T cell derived lymphokine which supports the proliferation and differentiation of early hematopoietic stem cells in vitro and has been speculated to play a comparable role in vivo (Ihle, and Weinstein, 1986; Ihle, 1988). A role for IL3 in the mechanisms by which retroviruses induce leukemias has been hypothesized based on several observations. Initially it was observed that there was a correlation between a T cell immune response to retroviruses and the latency and frequency of leukemias (Lee et al.1981a). It was subsequently demonstrated that the T cell response consisted, in part, of viral antigen specific helper T cells which produced IL3 following antigenic stimulation (Lee, and Ihle, 1981b). As a consequence of this immune response there is a dramatic increase in the cells proliferating in response to IL3 in vivo (Lee, and Ihle, 1981) which has been hypothesized to constitute an increased pool of progenitors for transformation.

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References

  • Akahoshi M, Oshimi K, Mizoguchi H, Okada M, Enomoto Y, Watanabe Y (1987) Myeloproliferative disorders terminating in acute megakaryoblastic leukemia with chromosome 3q26 abnormality. Cancer 60: 2654–2661

    Article  PubMed  CAS  Google Scholar 

  • Berg J. (1986). Potential metal-binding domains in nucleic acid binding proteins. Science 232: 485–487

    Article  PubMed  CAS  Google Scholar 

  • Bernstein R, Bagg A, Pinto M, Lewis D, Mendelow B (1986) Chromosome 3q21 abnormalities associated with hyperactive thrombopoiesis in acute blastic transformation of chronic myeloid leukemia. Blood 68: 652–657

    PubMed  CAS  Google Scholar 

  • Beug HM, Hayman J, Graf T (1982) Myeloblasts transformed by the avian acute leukemia virus E2 6 are hormone-dependent for growth and for expression of a putative myb-containing protein. EMBO J 1: 1063–1073

    Google Scholar 

  • Bitter MA, Neilly ME, LeBeau MM, Pearson MG, Rowley JD (1985) Rearrangements of chromosome 3 involving bands 3q21 and 3q2 6 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia. Blood 66: 1362–1370

    PubMed  CAS  Google Scholar 

  • Bordereaux D, Fichelson S, Sola B, Tambourin PE, Gisselbrecht S (1987) Frequent involvement of the fim-3 region in Friend murine leukemia virus-induced mouse myeloblastic leukemias. J Virol 61: 4043–4045

    PubMed  CAS  Google Scholar 

  • Carimer JF, Samarut J (1986) Chicken myeloid cells infected by retroviruses carrying the v-fps oncogene do not require exogenous growth factors to differentiate in vitro. Cell 44: 159–165

    Article  Google Scholar 

  • Cook WD, Metcalf D, Nicola NA, Burgess AW, Walker F (1985) Malignant transformation of a growth factor-dependent myeloid cell line by Abelson virus without evidence of an autocrine mechanism. Cell 41: 677–683

    Article  PubMed  CAS  Google Scholar 

  • Evans RM, Hollenberg SM (1988) Zinc fingers: gilt by association minireview. Cell 52: 1–3

    Article  PubMed  CAS  Google Scholar 

  • Holmes KL, Palaszynski E, Fredrickson TN, Morse HC 3d, Ihle JN (1985) Correlation of cell-surface phenotype with the establishment of interleukin 3-dependent cell lines from wild-mouse murine leukemia virus-induced neoplasms. Proc Natl Acad Sci USA 82: 6687–6691

    Article  PubMed  CAS  Google Scholar 

  • Honda BM, Roeder RG (1980) Association of a 5S gene transcription factor with 5S RNA and altered levels of the factor during cell differentiation. Cell 22: 19203–126

    Article  Google Scholar 

  • Ihle JN, Rein A, Mural R (1984) Immunological and virological mechanisms in retrovirus induced murine leukemogenesis. In: Klein G (ed) Advances in Viral Oncology, Vol 4. Raven Press, New York, pp 95–137

    Google Scholar 

  • Ihle JN, Weinstein Y (1986) Immunological regulation of hematopoietic/lymphoid stem cell differentiation by interleukin 3. Adv Immunol 39: 1–50

    Article  PubMed  CAS  Google Scholar 

  • Ihle JN (1988) The molecular and cellular biology of interleukin-3. In: Cruse JM, Lewis RE Jr (eds) The Year in Immunology. Karger, New York, in press

    Google Scholar 

  • Joyner A, Keller G, Phillips RA, Bernstein A (1983) Retrovirus transfer of a bacterial gene into mouse haematopoietic progenitor cells. Nature 305: 556–558

    Article  PubMed  CAS  Google Scholar 

  • Keller G, Paige C, Gilboa E, Wagner EF (1985) Expression of a foreign gene in myeloid and lymphoid cells derived from multipotent haematopoietic precursors. Nature 318: 149–154

    Article  PubMed  CAS  Google Scholar 

  • Klempnauer KH, Gonda T, Bishop JM (1982) Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene. Cell 31: 453–463

    Article  PubMed  CAS  Google Scholar 

  • Klempnauer KH, Ramsay G, Bishop JM, Moscovici MG, Moscovici C, McGrath JP, Levinson AD (1983) The product of the retroviral transforming gene v-myb is a truncated version of the protein encoded by the cellular oncogene c-myb. Cell 33: 345–355

    Article  PubMed  CAS  Google Scholar 

  • Lee JC, Ihle JN (1981) Increased responses to lymphokines are correlated with preleukemia in mice inoculated with Moloney leukemia virus. Proc Natl Acad Sci USA 78: 7712–7716

    Article  PubMed  CAS  Google Scholar 

  • Lee JC, Horak I, Ihle JN (1981a) Mechanisms in T-cell leukemogenesis. II. T-cell responses of preleukemic BALB/c mice to Moloney leukemia virus antigens. J Immunol 126: 715–722

    PubMed  CAS  Google Scholar 

  • Lee JC, Ihle JN (1981b) Chronic immune stimulation is required for Moloney leukemia virus-induced lymphomas. Nature 289: 407–409

    Article  PubMed  CAS  Google Scholar 

  • Lemischka IR, Raulet DH, Mulligan RC (1986) Developmental potential and dynamic behavior of hematopoietic stem cells. Cell 45: 917–927

    Article  PubMed  CAS  Google Scholar 

  • Miller J, McLachlan AD, Klug A (1985) Repetitive zinc-binding domains in the protein transcription factor IIIA from Xenopus oocytes. EMBO J 4: 1609–1614

    PubMed  CAS  Google Scholar 

  • Morishita K, Parker DS, Mucenski ML, Jenkins NA, Copeland NG, Ihle JN (1988) Retroviral activation of a novel gene encoding a zinc finger protein in IL-3-dependent myeloid leukemia cell lines. Cell 54: in press

    Google Scholar 

  • Moscovici MG, Jurdic P, Samarut J, Gazzolo L, Mura CV, Moscovici C (1983) Characterization of the hemopoietic target cells for the avian leukemia virus E26. Virology 129: 65–78

    Article  PubMed  CAS  Google Scholar 

  • Mucenski ML, Taylor BA, Ihle JN, Hartley JW, Morse HC 3d, Jenkins NA, Copeland NG (1988) Identification of a common ecotropic viral integration site, Evi-1, in the DNA of AKXD murine myeloid tumors. Mol Cell Biol 8: 301–308

    PubMed  CAS  Google Scholar 

  • Pelham HR, Brown DD (1980) A specific transcription factor that can bind either the 5S RNA gene or 5S RNA. Proc Natl Acad Sci USA 77: 4170–4174

    Article  PubMed  CAS  Google Scholar 

  • Pierce JH, Di Fiore PP, Aaronson SA, Potter M, Pumphrey J, Scott A, Ihle JN (1985) Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism. Cell 41: 685–693

    Article  PubMed  CAS  Google Scholar 

  • Rapp UR, Cleveland JL, Brightman K, Scott A, Ihle JN (1985) Abrogation of IL-3 and IL-2 dependence by recombinant murine retroviruses expressing v-myc oncogenes. Nature 317: 434–438

    Article  PubMed  CAS  Google Scholar 

  • Rubin CM, Larson RA, Bitter MA, Carrino JJ, LeBeau MM, Diaz MO, Rowley JD (1987) Association of a chromosomal 3:21 translocation with the blast phase of chronic myelogenous leukemia. Blood 70: 1338–1342

    PubMed  CAS  Google Scholar 

  • Shimazaki C, Fujita N, Nakanishi S, Nishio A, Haruyama H, Nakagawa M, Ijichi H, Nishida K, Misawa S (1986) Inversion of chromosome 3 in a case of chronic myelogenous leukemia with abnormal thrombopoiesis. Cancer Genet Cytogenet 20: 121–127

    Article  PubMed  CAS  Google Scholar 

  • Weinstein Y, Ihle JN, Lavu S, Reddy EP (198 6) Truncation of the c-myb gene by a retroviral integration in an interleukin-3 dependent myeloid leukemia cell line. Proc Natl Acad Sci USA 83: 5010–5014

    Article  PubMed  CAS  Google Scholar 

  • Weinstein Y, Cleveland JL, Askew DS, Rapp UR, Ihle JN (1987) Insertion and truncation of c-myb by MuLV in a myeloid cell line derived from cultures of normal hematopoietic cells. J Virol 61: 2339–2343

    PubMed  CAS  Google Scholar 

  • Williams DA, Lemischka IR, Nathans DG, Mulligan RC (1984) Introduction of new genetic material into pluripotent haematopoietic stem cells of the mouse. Nature 310: 476–480

    Article  PubMed  CAS  Google Scholar 

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Author notes

  1. K. Morishita, C. Bartholomew & D. Askew

    Present address: Department of Biochemistry, St. Jude Children’s Hospital, 332 North Lauderdale, Memphis, Tennessee, 38101, USA

Authors and Affiliations

  1. BRI-Basic Research Program, NCI-Frederick Cancer Research Facility, Frederick, Maryland, 21701, USA

    J. N. Ihle, K. Morishita, D. S. Parker, C. Bartholomew, D. Askew, A. Buchberg, N. A. Jenkins, N. Copeland & Y. Weinstein

  2. Department of Microbiology and Immunology, Ben Gurion University of the Negev, Beer Sheva, Israel

    Y. Weinstein

Authors
  1. J. N. Ihle
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  2. K. Morishita
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  3. D. S. Parker
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  4. C. Bartholomew
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  5. D. Askew
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  6. A. Buchberg
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  7. N. A. Jenkins
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  8. N. Copeland
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  9. Y. Weinstein
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Editor information

Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institutes, National Institutes of Health, Bethesda, MD, 20892, USA

    Grace L. C. Shen-Ong Ph. D.  & Michael Potter M. D.  & 

  2. Mammalia Genetics Laboratory, BRI - Basic Research Program, NCI - Frederick Cancer Research Facility, MD, 21701, USA

    Neal G. Copeland Ph. D.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Ihle, J.N. et al. (1989). Mechanisms in the Transformation of IL3-Dependent Hematopoietic Stem Cells. In: Shen-Ong, G.L.C., Potter, M., Copeland, N.G. (eds) Mechanisms in Myeloid Tumorigenesis 1988. Current Topics in Microbiology and Immunology, vol 149. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74623-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-74623-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74625-3

  • Online ISBN: 978-3-642-74623-9

  • eBook Packages: Springer Book Archive

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