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The Pathology of Murine Myelogenous Leukemias

  • Conference paper
Mechanisms in Myeloid Tumorigenesis 1988

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 149))

Abstract

Acute myelogenous leukemias (AML) can have a wide range of morphological variation, both in humans and in mice. Human AMLs have been divided into seven subtypes based on morphology of the leukemic cells and certain cytochemical reactions, which depend on the type of cellular differentiation and the degree of maturation (Bennett et al., 1976, 1985). Correlation of these morphological subtypes with cytogenetic abnormalities has proved useful and interesting (Yunis et al., 1984; Fourth International Workshop, 1984), while correlation with prognosis and response to treatment is less significant (Mertelsmann et al., 1980). The finding of distinctive translocations in different subtypes argues that a) the subtypes are biologically distinct albeit related diseases with different antecedent leukemogenic events and b) mutation/alteration of gene(s) located at or near the translocation point is involved in the genesis of phenotype of the particular subtype to which the translocation is associated. The identification and characterization of genes significantly altered by the subtype-specific translocation should yield insight into both 1eukemogenesis and the control of normal differentiation.

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Authors and Affiliations

  1. Department of Pathology, Brigham and Women’s Hospital, 75 Francis Street, Boston, MA, 02115, USA

    Archibald S. Perkins

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  1. Archibald S. Perkins
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Editors and Affiliations

  1. Laboratory of Genetics, National Cancer Institutes, National Institutes of Health, Bethesda, MD, 20892, USA

    Grace L. C. Shen-Ong Ph. D.  & Michael Potter M. D.  & 

  2. Mammalia Genetics Laboratory, BRI - Basic Research Program, NCI - Frederick Cancer Research Facility, MD, 21701, USA

    Neal G. Copeland Ph. D.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Perkins, A.S. (1989). The Pathology of Murine Myelogenous Leukemias. In: Shen-Ong, G.L.C., Potter, M., Copeland, N.G. (eds) Mechanisms in Myeloid Tumorigenesis 1988. Current Topics in Microbiology and Immunology, vol 149. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74623-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-74623-9_1

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