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Human Endogenous Retrovirus-like Sequences

  • R. Brack-Werner
  • C. Leib-Mösch
  • T. Werner
  • V. Erfle
  • R. Hehlmann
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

One of the most salient features of the replication strategy used by retroviruses is the transcription of the retroviral (RNA) genome into DNA followed by integration of this DNA product into the host cell genome. The integrated viral DNA copy, termed “provirus”, can then serve as a template for the synthesis of further infectious virus particles. Stably integrated proviruses have been found to also persist in the germ line of animal cells. In this case, they have become an endogenous constituent of their host cell’s genome and are passed on as stable Mendelian genes from one generation to the next.

Keywords

Mouse Mammary Tumor Virus Avian Leukosis Virus Proviral Sequence Murine Mammary Tumor Virus Simian Sarcoma Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. Brack-Werner
    • 1
  • C. Leib-Mösch
    • 3
  • T. Werner
    • 2
  • V. Erfle
    • 1
  • R. Hehlmann
    • 4
  1. 1.GSF-Abt. für Molekulare ZellpathologieNeuherbergGermany
  2. 2.GSF-Institut für SäugetiergenetikNeuherbergGermany
  3. 3.Medizinische Poliklinik der Universität MünchenMunichGermany
  4. 4.III. Medizinische Klinik Mannheim der Universität HeidelbergMannheim 31Germany

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