HIV-I Replication Requires an Intact Integrase Reading Frame

  • H. D. Buchow
  • E. Tschachler
  • R. C. Gallo
  • M. ReitzJr.
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Human immunodeficiency virus type I (HIV-I), is a human retrovirus that is the causative agent of acquired immune deficiency syndrome (AIDS). Retroviruses replicate through a DNA intermediate. After initial synthesis of unintegrated DNA the insertion of that DNA into the host cell genome is thought to be a required step in the retroviral life cycle [1].

Keywords

Codon Leukemia Tated 

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Reference

  1. 1.
    Varmus H, Swanstrom R (1984) Replication of retroviruses. In. Weiss R et al. (eds) RNA tumor viruses, 2nd ed. Cold Spring Harbor Lab, New YorkGoogle Scholar
  2. 2.
    Fisher AG et al. (1985) A molecular clone of HTLV-III with biological activity. Nature 316: 262–265PubMedCrossRefGoogle Scholar
  3. 3.
    Panganiban AT (1985) Retroviral DNA integration. Cell 42: 5–6PubMedCrossRefGoogle Scholar
  4. 4.
    Panganiban A, Temin H (1984) The retro-virus POL gene encodes a product required for DNA integration: identification of a retrovirus INT locus. Proc Natl Acad Sci USA 81: 7885–7889PubMedCrossRefGoogle Scholar
  5. 5.
    Zoller MJ, Smith M (1984) Oligonucle-otide-directed mutagenesis: a simple method using two oligonucleotide primers and a single-stranded DNA template. DNA 3: 479–488PubMedCrossRefGoogle Scholar
  6. 6.
    Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning. A laboratory manual. Cold Spring Harbor Lab, New YorkGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • H. D. Buchow
    • 1
  • E. Tschachler
    • 1
  • R. C. Gallo
    • 1
  • M. ReitzJr.
    • 1
  1. 1.National Institutes of HealthNational Cancer InstituteBethesdaUSA

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