HIV-I Replication Requires an Intact Integrase Reading Frame
Human immunodeficiency virus type I (HIV-I), is a human retrovirus that is the causative agent of acquired immune deficiency syndrome (AIDS). Retroviruses replicate through a DNA intermediate. After initial synthesis of unintegrated DNA the insertion of that DNA into the host cell genome is thought to be a required step in the retroviral life cycle .
KeywordsHost Cell Genome
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