Cell Lineage Specificity of Chromatin Configuration and Gene Expression in Haemopoietic Progenitor Cells

  • A. M. Ford
  • L. E. Healy
  • S. M. Watt
  • E. Spooncer
  • T. M. Dexter
  • H. V. Molgaard
  • M. F. Greaves
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Haemopoietic stem cells have the potential to activate up to eight distinct cell lineage specific genetic programmes [1]. The mechanisms of cell lineage choice or commitment are fundamental to developmental biology in general and are beginning to be unravelled at least in invertebrates (e.g., Drosophila, Nematodes, slime moulds). Transacting DNA binding proteins that directly or indirectly regulate gene transcription are central players in the game [2], as are inductive cellular interactions [3]. In haemopoietic differentiation, it is clear that selective progenitor-stromal cell interactions involving both adhesive and growth factor recognition [4–7] are playing a role in early decision-making but the basic mechanisms whereby uni-lineage adoption is made are still obscure.

Keywords

Leukemia Radium Lineage Choice Glycosaminoglycan Rine 

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. M. Ford
    • 1
  • L. E. Healy
    • 1
  • S. M. Watt
    • 1
  • E. Spooncer
    • 2
  • T. M. Dexter
    • 2
  • H. V. Molgaard
    • 1
  • M. F. Greaves
    • 1
  1. 1.Leukaemia Research Fund Centre, Chester Beatty LaboratoriesInstitute of Cancer ResearchLondonUK
  2. 2.Paterson LaboratoriesChristie Hospital and Holt Radium InstituteWithington, ManchesterUK

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