Modification of HLA Expression as a Possible Factor in the Pathogenesis of Burkitt’s Lymphoma
According to the Kiel classification, Burkitt’s lymphoma (BL) is a high-grade malignant non-Hodgkin’s lymphoma of the B-cell lineage. In all the BL cells one finds a gene translocation which can activate the c-myc oncogen. In addition, 95% of the endemic-type BLs are infected with the Epstein-Barr virus (EBV). In vitro infection with EBV can transform peripheral blood B-cells into immortalized nonmalignant lymphoblastoid cell lines (LCLs). LCLs can also grow out spontaneously from peripheral blood lymphocytes of EBV-positive donors after the removal of T cells or their inhibition by cyclosporin A in vitro. In vivo EBV-infected cells are normally controlled by the immune system. Immuno-suppression leads to a higher risk of EBV-associated oligoclonal lymphoma.
KeywordsChromium Lymphoma Leukemia Cyclosporin
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