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Modification of HLA Expression as a Possible Factor in the Pathogenesis of Burkitt’s Lymphoma

  • R. Voltz
  • W. Jilg
  • H. Wolf
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

According to the Kiel classification, Burkitt’s lymphoma (BL) is a high-grade malignant non-Hodgkin’s lymphoma of the B-cell lineage. In all the BL cells one finds a gene translocation which can activate the c-myc oncogen. In addition, 95% of the endemic-type BLs are infected with the Epstein-Barr virus (EBV). In vitro infection with EBV can transform peripheral blood B-cells into immortalized nonmalignant lymphoblastoid cell lines (LCLs). LCLs can also grow out spontaneously from peripheral blood lymphocytes of EBV-positive donors after the removal of T cells or their inhibition by cyclosporin A in vitro. In vivo EBV-infected cells are normally controlled by the immune system. Immuno-suppression leads to a higher risk of EBV-associated oligoclonal lymphoma.

Keywords

Latent Membrane Protein Gene Translocation Kiel Classification Restricted CTLs Pettenkofer Institute 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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    Rooney CM, Rowe M, Wallace LE, Rickinson AB (1985) Epstein-Barr virus-positive Burkitt’s lymphoma cells not recognized by virus-specific T-cell surveillance. Nature 317: 629–631PubMedCrossRefGoogle Scholar
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    Torsteinsdottir S, Masucci MG, Ehlin- Henriksson B, Brautbar C, Ben Bassat H, Klein G, Klein E (1986) Differentiation-de-pendent sensitivity of human B-cell-derived lines to major histocompatibility complex- restricted T-cell cytotoxicity. Proc Natl Acad Sci USA 83: 5620–5624PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. Voltz
    • 1
  • W. Jilg
  • H. Wolf
  1. 1.Max von Pettenkofer InstituteUniversity of MunichMünchen 2Germany

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