Modification of HLA Expression as a Possible Factor in the Pathogenesis of Burkitt’s Lymphoma
According to the Kiel classification, Burkitt’s lymphoma (BL) is a high-grade malignant non-Hodgkin’s lymphoma of the B-cell lineage. In all the BL cells one finds a gene translocation which can activate the c-myc oncogen. In addition, 95% of the endemic-type BLs are infected with the Epstein-Barr virus (EBV). In vitro infection with EBV can transform peripheral blood B-cells into immortalized nonmalignant lymphoblastoid cell lines (LCLs). LCLs can also grow out spontaneously from peripheral blood lymphocytes of EBV-positive donors after the removal of T cells or their inhibition by cyclosporin A in vitro. In vivo EBV-infected cells are normally controlled by the immune system. Immuno-suppression leads to a higher risk of EBV-associated oligoclonal lymphoma.
KeywordsLatent Membrane Protein Gene Translocation Kiel Classification Restricted CTLs Pettenkofer Institute
Unable to display preview. Download preview PDF.
- 3.Torsteinsdottir S, Masucci MG, Ehlin- Henriksson B, Brautbar C, Ben Bassat H, Klein G, Klein E (1986) Differentiation-de-pendent sensitivity of human B-cell-derived lines to major histocompatibility complex- restricted T-cell cytotoxicity. Proc Natl Acad Sci USA 83: 5620–5624PubMedCrossRefGoogle Scholar