Induction of Nonspecific Cell-Mediated Cytotoxicity: A Multisignal Event and its Cellular Regulation
Nonspecific cytotoxic cells provide a major line of defense against tumor. While natural killer (NK) cells display spontaneous, non-MHC-restricted killing activity, both NK and non-NK lymphocytes can be induced by lymphokines to exhibit enhanced nonspecific cytotoxicity against tumor, including NK-resistant targets [1–3]. The latter activity is mediated by a heterogeneous cell population commonly termed lymphokine-activated killer (LAK) cells [2–4]. According to the initial concept, nonspecific LAK killing is generated via exposure to interleukin 2 (IL-2) of peripheral blood lymphocytes [5, 6]. Most of the LAK activity appears to be mediated by NK cells stimulated with IL-2; however, recent studies suggest that induction of MHC-unrestricted lymphokine-activated killing is a more complex phenomenon requiring a multitude of cellular and noncellular signals [2–4, 7-10].
KeywordsToxicity Lymphoma EDTA Leukemia Sarcoma
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