Effect of Natural and Synthetic Peptides on the Biological Function of Leukemic Cells

  • B. Kazanowska
  • J. Bogusławska-Jaworska
  • D. Konopińska
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)


The goal of this work was to study the influence of some naturally occurring peptides and their analogs on the impaired biological properties of blood cells derived from leukemic patients. The effect of human tuftsin and of the insect neuropetide, proctolin, and their synthetic derivatives on the phagocytosis of granulocytes and the influence of proctolin and its analogs on the blastic transformation of lymphocytes were investigated.


Acute Lymphoblastic Leukemia Healthy Child Phagocytic Activity Leukemic Patient Blastic Transformation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kazanowska B, Bogusławska-Jaworska J, Konopińska D, Rodziewicz-Magott B (1988) The influence of proctolin and its analogs on the blastic transformation of ALL lymphocytes. Arch Immunol Ther Exp (Warsz) (in press).Google Scholar
  2. 2.
    Kazanowska B, Steuden W, Bogusławska-Jaworska B, Konopińska D (1987) The influence of synthetic tuftsin and its analogs on the function of granulocytes of children with ALL. Arch Immunol Ther Exp (Warsz) 35: 169Google Scholar
  3. 3.
    Konopińska D, Kazanowska B, Sobotka W, Bogusławska-Jaworska J (1986) An insect neuropeptide, proctolin. A new synthesis and its property of restoration of phagocytosis by defective human PMN leukocytes. Biull Pol Acad Sci 34: 327Google Scholar
  4. 4.
    Konopińska D, Luczak M, Wleklik M, Gumulka S, Kazanowska B (1983) Elongated tuftsin analogs-synthesis and biological investigation. Ann NY Acad Sci 419: 35PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. Kazanowska
    • 1
  • J. Bogusławska-Jaworska
    • 1
  • D. Konopińska
    • 2
  1. 1.Department of HematologyMedical Academy of WrocławPoland
  2. 2.Institute of ChemistryUniversity of WrocławPoland

Personalised recommendations