The Effect of Human and Rat Fetal Bone on Hematopoiesis In Vitro and In Vivo

  • B. V. Afanasyev
  • V. A. Shatrov
  • N. Balayan
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)


Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a regulatory glycoprotein necessary for the proliferation, maturation, and survival of myeloid cells [4]. Myelopoiesis is enhanced when recombinant human (rh) GM-CSF is given to mice, monkeys [6], and some patients with various forms of neutropenia [3, 5]. The clinical use of rhGM-CSF infusions is under intensive investigation now.


Acute Myeloid Leukemia Granulocyte Macrophage Colony Stimulate Factor Trephine Biopsy Fetal Bone Bone Marrow Trephine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Afanasyev BV, Tiranova SA, Kulibaba TG, Zubarovskaya LS, Bolshakova GD, Zabelina TS (1983) Cloning of human hemopoietic cells in the “agar drop-liquid medium” system. Ther Arch (USSR) 8: 114Google Scholar
  2. 2.
    Golde DW, Cline MJ (1973) Growth of human bone marrow in liquid culture. Blood 41: 45PubMedGoogle Scholar
  3. 3.
    Groopman JE, Mitsuyasu RT, DeLeo MJ, Oette DH, Golde DW (1987) Effect of recombinant human granulocyte macrophage colony stimulating factor on myelopoiesis in the acquired immunodeficiency syndrom. N Engl J Med 317: 593PubMedCrossRefGoogle Scholar
  4. 4.
    Metealf D (1977) Haemopoietic colonies. Springer,Berlin Heidelberg New YorkGoogle Scholar
  5. 5.
    Nemunaitis J, Singer JW, Buckner CD, Hill R, Storb R, Thomas ED, Appelbaum FR (1988) Use of recombinant human granulocyte macrophage colony stimulating factor (rh GM-CSF) in autologous marrow transplantation for lymphoid malignancies. Blood 72: 834PubMedGoogle Scholar
  6. 6.
    Nienhuis AW, Donahue RE, Karisson S, Clark SC, Agricola B, Antihoff N, Pierce JE, Turner P, Anderson WF, Nathan DG (1987) Recombinant human granulocyte macrophage colony stimulating factor ( GM-CSF) shortens the period of neutropenia after autologous bone marrow transplantation in a primate model. J Clin Invest 80: 573PubMedCrossRefGoogle Scholar
  7. 7.
    Pierce GB (1983) The cancer cell and its control by the embryo. Am J Pathol 113: 117PubMedGoogle Scholar
  8. 8.
    Zubarovskaya LS, Afanasyev BV, Smirnova G A, Lukasheva TN, Patterson D, Shishkov AL, Balayan LN, Ostrovsky AM (1985) Colony-stimulating activity of bone marrow trephanobiopsies of patients with different pathological conditions of the blood system. Ther Arch (USSR) 7: 22Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • B. V. Afanasyev
    • 1
  • V. A. Shatrov
    • 1
  • N. Balayan
    • 1
  1. 1.Department of Bone Marrow TransplantationN.N. Petrov Institute of OncologyLeningardUSSR

Personalised recommendations