Simultaneous Presentation of B- and T-Cell Malignant Lymphoma

  • F. E. Cotter
  • P. A. Hall
  • B. D. Young
  • T. A. Lister
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)


Multiclonal NHL of the B-cell type has been described [1, 2], most often when two histological types of lymphoma have been noted in simultaneous or successive biopsies. This occurs predominantly when follicular centre cell (FCC) histology converts into a large cell diffuse histology [2]. Multiclonal disease of the B-cell type has been noted in heavily immunosuppressed patients [3]. Reports of composite lymphoma with diffuse T-cell histology arising from co-existant FCC have been described on morphological and immunological evidence [4–6]; however, no DNA analysis was reported. Recently, a multiclonal lymphoma, confirmed by DNA analysis, was reported with sequential B- and T-cell clones [7] in a patient with autoimmune disease who received chemotherapy for the initial B-cell lymphoma.


Follicular Lymphoma Imperial Cancer Research Fund Composite Lymphoma Rearrange Band Follicular Centre Cell 
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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. E. Cotter
    • 1
  • P. A. Hall
    • 2
  • B. D. Young
    • 1
  • T. A. Lister
    • 1
  1. 1.Imperial Cancer Research Fund, Department of Medical OncologySt. Bartholomew’s HospitalLondonUK
  2. 2.Department of HistopathologySt. Bartholomew’s HospitalLondonUK

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