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Simultaneous Presentation of B- and T-Cell Malignant Lymphoma

  • F. E. Cotter
  • P. A. Hall
  • B. D. Young
  • T. A. Lister
Conference paper
Part of the Haematology and Blood Transfusion / Hämatologie und Bluttransfusion book series (HAEMATOLOGY, volume 32)

Abstract

Multiclonal NHL of the B-cell type has been described [1, 2], most often when two histological types of lymphoma have been noted in simultaneous or successive biopsies. This occurs predominantly when follicular centre cell (FCC) histology converts into a large cell diffuse histology [2]. Multiclonal disease of the B-cell type has been noted in heavily immunosuppressed patients [3]. Reports of composite lymphoma with diffuse T-cell histology arising from co-existant FCC have been described on morphological and immunological evidence [4–6]; however, no DNA analysis was reported. Recently, a multiclonal lymphoma, confirmed by DNA analysis, was reported with sequential B- and T-cell clones [7] in a patient with autoimmune disease who received chemotherapy for the initial B-cell lymphoma.

Keywords

Follicular Lymphoma Imperial Cancer Research Fund Composite Lymphoma Rearrange Band Follicular Centre Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Sklar J, Cleary ML, Thielamanns K, Gralow J, Warnke R, Levy R (1984) Biclonal B-cell lymphomas. N Engl J Med 311: 20–27PubMedCrossRefGoogle Scholar
  2. 2.
    Siegelman MH, Cleary ML, Warnke R, Sklar J (1985) Frequent biclonality and Ig gene alterations among B-cell lymphomas that show multiple histological forms. J Exp Med 161: 850–863PubMedCrossRefGoogle Scholar
  3. 3.
    Cleary ML, Sklar J (1984) Lymphoproliferative disorders in cardiac transplant recipients are multiclonal lymphomas. Lancet ii: 489–493Google Scholar
  4. 4.
    York JC II, Cousar JB, Glick AD, Flexner JM, Stein R, Collins RD (1985) Morphological and immunologic evidence of composite B-and T-cell lymphomas. Am J Clin Pathol 84: 35–43PubMedGoogle Scholar
  5. 5.
    Aisenberg AC, Block KJ, Wilkes BM (1981) Malignant lymphoma with dual B-and T-cell markers. J Exp Med 154: 1709–1714PubMedCrossRefGoogle Scholar
  6. 6.
    Jeannette JC, Reddick RL, Saunders AW, Wilkman AS (1982) Diffuse T-cell lymphomas preceded by nodular lymphoma. Am J Clin Pathol 78: 242–248Google Scholar
  7. 7.
    Hu E, Weiss LM, Warnke R, Sklar J (1987) Non-Hodgkin’s lymphomas containing both B-and T-cell clones. Blood 70: 287–292PubMedGoogle Scholar
  8. 8.
    Hall PA, Steam PM, Butler MG, d’Ardenne AJ (1987) Acetone periodate lysine paraformaldehyde ( PLP) fixation and improved morphology for frozensection immunohistochemistry. Histopathology 11: 93–101PubMedCrossRefGoogle Scholar
  9. 9.
    Cotter FE, Hall PA, Young BD (1988) Extraction of DNA from frozen section with simultaneous histological examination. J Clin Pathol 41: 1125–1126PubMedCrossRefGoogle Scholar
  10. 10.
    Southern EM (1975) Detection of specific sequences among DN fragments separated by gel electrophoresis. J Mol Biol 98: 503–517PubMedCrossRefGoogle Scholar
  11. 11.
    Feinberg AP, Vogelstein B (1983) A technique for radiolabelling DNA restriction endonuclease fragments to a high specific affinity. Anal Biochem 132: 6–13PubMedCrossRefGoogle Scholar
  12. 12.
    Nishida Y, Miki T, Hidsajima H, Honjo T (1982) Cloning of human immunoglobulin & chain genes: evidence for multiple CE genes. Proc Natl Acad Sci USA 79: 3833–3837PubMedCrossRefGoogle Scholar
  13. 13.
    Cleary ML, Sklar J (1985) Nucleotide sequence of a t (14; 18) chromosomal breakpoint in follicular lymphomas and a demonstration of a breakpointcluster region near a transcriptionally active locus on chromosome 18. Proc Natl Acad Sci USA 82: 7439–7443PubMedCrossRefGoogle Scholar
  14. 14.
    Furley AJ, Mizutani S, Weilbaecher K, Dhaliwal HS, Ford AM, Chan LC, Molgaard HV, Toyonago B, Mak T, van den Elsen P, Gold D, Terhoist C, Greaves MF (1986) Developmentally regulated rearrangement and expression of genes encoding the T-cell receptor-T3 complex. Cell 46: 75–87PubMedCrossRefGoogle Scholar
  15. 15.
    Maniatis T, Fritsch EF, Sambrook J (1982) Molecular cloning: a laboratory manual. Cold Spring Harbor Laboratory, Cold Spring Harbor NY, p 387–389Google Scholar
  16. 16.
    Weiss LM, Warnke RA, Sklar J, Cleary ML (1987) Molecular analysis of the t(14; 18) chromosomal translocation in malignant lymphomas. N Engl J Med 317: 1185–1189PubMedCrossRefGoogle Scholar
  17. 17.
    Yunis JJ, Frizzerà G, Oken MM, McKenna J, Theologides A, Arnesen M (1987) Multiple recurrent genomic defects in follicular lymphomas: a possible model for cancer. N Engl J Med 316: 79–83PubMedCrossRefGoogle Scholar
  18. 18.
    Gallagher CJ, Gregory WM, Jones AE, Stansfeld AG, Richards MA, Dhaliwal HS, Malpas JS, Lister TA (1986) Follicular lymphomas: prognostic factors for response and survival. J Clin Oncol 4: 1470–1480PubMedGoogle Scholar
  19. 19.
    Qazi R, Aisenberg AG, Long JC (1976) The natural history of nodular lymphoma. Cancer 37: 1923–1927PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. E. Cotter
    • 1
  • P. A. Hall
    • 2
  • B. D. Young
    • 1
  • T. A. Lister
    • 1
  1. 1.Imperial Cancer Research Fund, Department of Medical OncologySt. Bartholomew’s HospitalLondonUK
  2. 2.Department of HistopathologySt. Bartholomew’s HospitalLondonUK

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