Combination Therapy of Chenodeoxycholic Acid and Ursodeoxycholic Acid
Bile acid therapy has become well established as nonsurgical treatment in selected patients with cholesterol gallstones since chenodeoxycholic acid (cheno) and, later on, ursodeoxycholic acid (urso) were introduced in the early 1970s and 1980s, respectively.
KeywordsBile Acid Saturation Index Ursodeoxycholic Acid Chenodeoxycholic Acid Cholesterol Gallstone
Unable to display preview. Download preview PDF.
- 2.Von Bergmann K, Epple-Gutsfeld M, Leiss O (1984) Differences in the effects of chenodeoxy-cholic and ursodeoxycholic acid in biliary lipid secretion and bile acid synthesis in patients with gallstones. Gastroenterology 87: 136–143Google Scholar
- 5.Miyai K, Toyota N, Jones HM, Gochman N (1982) Protective effect of ursodeoxycholic acid against cholestatic and hepatotoxic effects of lithocholic acid ( Abstract ). Hepatology 2: 705Google Scholar
- 6.Krol T, Kitamura T, Miyai K, Hardison W (1983) Tauroursodeoxycholate reduces ductular proliferation in bile duct-ligated hamsters (Abstract). Hepatology 3: 881Google Scholar
- 7.Tanikawa K, Kawahara T, Kumashiro R et al. (1986) Effects of bile acids on the cultured hepatocyte and Kupffer cell (Abstract). Hepatology 6: 779Google Scholar
- 13.Roehrkasse R, Fromm H, Malavolti M, Tunuguntla AK, Ceriak S (1986) Gallstone dissolution treatment with a combination of chenodeoxycholic and ursodeoxycholic acid. Studies of safety, efficacy and effects on bile lithogenicity, bile acid pool and serum lipids. Dig Dis Sci 31: 1032–1040PubMedCrossRefGoogle Scholar
- 14.Lanzini A, Facchinetti D, Rossi A, Muiesan G (1989) Cheno plus urso (CDCA + UDCA) combination therapy: dose-response effect on cholesterol saturation index (SI) of gallbladder bile (Abstract). 1st International Lugano Symposium on Biliary Physiology and Diseases. Strategies for the treatment of hepatobiliary diseases. 15–17 June 1989, LuganoGoogle Scholar
- 16.Thistle JL (1987) Dissolution of gallstones using ursodeoxycholic acid with or without chenodeoxycholic acid or taurine. In: Paumgartner G, Stiehl A, Gerok W (eds), Biological effects of bile acids. MTP Press, Lancaster, pp 353–354Google Scholar
- 17.Kawamoto T, Horiuchi I, Hino F, Okahashi M, Kajiyama G (1984) Combination treatment with different doses of urso (U) and chenodeoxycholic acid (C) in patients with cholesterol gallstones (Abstract). Proceedings of the VIIIth International Bile Acid Meeting, Berne, p 183Google Scholar
- 18.Czygan P (1987) Efficacy of combined ursodeoxycholic and chenodeoxycholic acid treatment. In: Paumgartner G, Stiehl A, Gerok W (eds) Biological effects of bile acids. MTP Press, Lancaster, pp 343–344Google Scholar
- 21.Mazzella G, Labate AMM, Malavolti M, Petronelli A, Roda A, Barbara L (1983) The effect of ursodeoxycholic acid administration on bile lipid composition in man: comparison of bedtime versus mealtime administration. Curr Ther Res 30: 551–557Google Scholar
- 22.Northfield TC, Lanzini A, Jazrawi R, Maudgal DP, Kupfer R (1985) Methods of improving the efficacy of litholitic therapy. In: Paumgartner G, Stiehl A, Gerok W (eds) Enterohepatic circulation of bile acids and sterol metabolism. MTP Press, Lancaster, pp 335–350Google Scholar
- 23.Carey MC, Ko G (1979) The importance of total lipid concentration in determining cholesterol solubility in bile and the development of critical tables for calculating “percent cholesterol saturation” with a correction factor for ursodeoxycholic-rich bile. In: Paumgartner G, Stiehl A, Gerok W (eds) Biological effects of bile acids. MTP Press, Lancaster, pp 299–308Google Scholar