The Quality of Life of Hypertensive Patients in Long-term Studies

  • A. Distler
Part of the Bayer AG Centenary Symposium book series (BAYER)


Quality of life is an important aspect of any kind of drug treatment. It is obvious that the influence drug treatment exerts on the quality of life is of secondary importance when the disease in question poses an immediate threat to life, such as is the case with cancer. In such cases, the patient is usually willing even to accept a marked deterioration in quality of life provided that there is hope of being cured by the treatment. The question as to the adverse influence exerted on the quality of life by drug treatment gains decisive significance, however, when applied to diseases which do not pose an immediate threat to life and which, as a rule, even run their course without symptoms, as is the case, for example, with hypertension. Chronic hypertension is treated because untreated hypertension in the long-run is known to be associated with increased morbidity and mortality due to left ventricular failure, coronary heart disease, or stroke. Other consequences of untreated hypertension may be acceleration of hypertension or the development of malignant hypertension. As regards treatment of hypertension, it seems particularly important to use drugs which do not adversely affect the quality of life, since the drugs have to be taken by the patient for many years or even for a lifetime.


Hypertensive Patient Sexual Dysfunction Mild Hypertension Malignant Hypertension Placebo Control Group 
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  1. 1.
    Bulpitt CJ, Dollery CT (1973) Side effects of hypotensive agents evaluated by a self-administered questionnaire. Br Med J 3: 485PubMedCrossRefGoogle Scholar
  2. 2.
    Croog SH, Levine S, Testa MA, Brown B, Bulpitt CJ, Jenkins CD, Klerman GL, Williams GH (1986) The effects of antihypertensive therapy on the quality of life. N Engl J Med 314: 1657PubMedCrossRefGoogle Scholar
  3. 3.
    Curb JD, Borhani NO, Blaszkowski TP, Zimbaldi N, Fotiu S, Williams W (1985) Long-term surveillance for adverse effects of antihypertensive drugs. JAMA 253: 3263PubMedCrossRefGoogle Scholar
  4. 4.
    Jachuck SJ, Brierley H, Jachuck S, Willcox PM (1982) The effect of hypotensive drugs on the quality of life. J R Coll Gen Pract 32: 103PubMedGoogle Scholar
  5. 5.
    Medical Research Council Working Party (1985) MRC trial of treatment of mild hypertension: principal results. Br Med J 291: 97CrossRefGoogle Scholar
  6. 6.
    Veterans Administration Co-operative Study Group on Antihypertensive Agents (1970) Effects of treatment on morbidity in hypertension — II. Results in patients with diastolic blood pressure averaging 90 through 114 mmHg JAMA 213: 1143Google Scholar
  7. 7.
    Wilhelmsen L, Berglund G, Elmfeldt D, Fitzsimons T, Holzgreve H, Hosie J, Hörnkvist PE, Pennert K, Tuomilehto H, Wedel H (1987) Beta-blockers versus diuretics in hypertensive men: main results from the HAPPHY trial. J Hypertens 5: 561PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • A. Distler
    • 1
  1. 1.Medizinische Klinik und PoliklinikFU Berlin, Universitätsklinikum SteglitzBerlin 45Federal Republic of Germany

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