Hirsutism must be regarded as an androgen-mediated symptom. In men virilization is a normal occurrence at puberty and is closely related to an increase in testicular function, but in women virilization is an unnatural phenomenon. The clinical spectrum of virilization includes acne, seborrhea oleosa, hirsutism, androgenetic alopecia, and more severe manifestations such as deepening of the voice, clitorimegaly, and pectoral muscle hypertrophy. The clinical picture of hirsutism may range from mild beard growth to increased coarse body hair of the male type, with or without menstrual disorders. The pathogenesis of hirsutism is apparently linked to androgenic hormones. The physiological role of androgens, namely testosterone, is well defined in men: testosterone is involved in genital development, the process of sperm maturation, the regulation of gonadotropin secretion by the pituitary, the growth of sexual hair, and the regulation of sexuality; moreover, it represents a most potent anabolic hormone.
KeywordsFree Testosterone Androgen Production Plasma Testosterone Level Testosterone Undecanoate Hirsute Woman
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- Andreson DC (1976) The role of sex hormone binding globuline in health and disease. In: James VHT, Serio M, Giusti G (eds) The endocrine function of the human ovary. Academic, LondonGoogle Scholar
- Gehring U, Tomkins GM, Ohno S (1971) Effect of the androgen-insensitive mutation on a cytoplasmic receptor for dihydrotestosterone. Nature 232:106–107Google Scholar
- Geisthövel F, Rieger B, Geyer H, Peters F, Sandow J (1986) Effect of long-term s.c. infusion of a Gn-RH agonist (Buserelin) on pituitary and ovarian function. Acta Endocrinol Copenh [Suppl] 274:90Google Scholar
- Heinrichs WL, Karsenia R, Wyss R, Lehmann WL (1969) Testicular feminization an apparent enzyme defect. Clin Res 17:143Google Scholar
- Kaiser R, Karl HJ, Daume E (1963) Zyklusstörungen und Hirsutismus. Geburtshilfe Frauenheilkd 23:593–614Google Scholar
- Kirschner MA, Zucker IR, Jespersen DL (1976) Ovarian and adrenal vein catheterization studies in women with idiopathic hirsutism. In: James VHT, Serio M, Giusti G (eds) The endocrine function of the human ovary. Academic, LondonGoogle Scholar
- Kuttenn F, Mauvais-Jarvis P (1975) Testosterone 5a-reduction in the skin of normal subjects and of patients with abnormal sex development. Acta Endocrinol (Copenh) 79:164–176Google Scholar
- Ludwig E (1969) Hypertrichosen und Hirsutismus. Z Allgemeinmed Landarzt 45:754–762Google Scholar
- Mercier-Bodard C, Alfsen A, Baulieu EE (1970) Sex steroid binding plasma protein (SBP). Acta Endocrinol Copenh [Suppl] 147:204Google Scholar
- Schürmeyer T, Wickings EJ, Freischem CW, Nieschlag E (1983) Saliva and serum testosterone following oral testosterone undecanoate administration in normal and hypogonadal men. Acta Endocrinol (Copenh) 102:456–462Google Scholar
- Shah PN (1957) Human body hair (a quantitative study). Am J Obstet Gynecol 72:1255Google Scholar
- Vermeulen A (1977) Transport and distribution of androgens at different ages. In: Martin L, Motta M (Eds) Androgens and antiandrogens. Raven, New YorkGoogle Scholar
- Weed JC (1955) Management of hirsutism in the female. Am J Obstet Gynecol 45:1347Google Scholar