Zusammenfassung
Eine Pankreas-Nierentransplantation kann als Therapie der Wahl bei urämischen Diabetikern angesehen werden. Wir berichten über die Stoffwechseleffekte einer Pankreas- und Nierentransplantation bei 23 urämischen Diabetikern. Das transplantierte Pankreas zeigt unmittelbar nach Re-Vaskularisation eine gute Funktion: das Serum-C-Peptid, vor dem Eingriff negativ, steigt an; ein klassischer Stimulus für die Insulinsekretion, Glukose, bewirkt eine dynamische Insulinfreisetzung bei intravenöser oder oraler Gabe der Glukose. Der Blutzuckerverlauf nach oraler Glukosebelastung zeigt aber eine verzögerte Rückkehr zur Normoglykämie. Das transplantierte Pankreas reagiert auch regelrecht auf andere Insulinstimulation, wie Aminosäuren. Die 24-Stunden-Profile für den Blutzucker und die freie Seruminsulinkonzentration und andere Faktoren beweisen, daß eine normale Blutzuckerhomöostase unter Alltagsbedingungen erreicht werden kann mit allerdings einer leichten Hyperglykämie in der postprandialen Phase und einer leichten Hyperinsulinämie während der Nacht. Die Gründe hierfür werden diskutiert. Die Langzeitauswirkungen der beobachteten dynamischen Insulinsubstitution auf die diabetischen Sekundärkomplikationen schließlich müssen noch untersucht werden.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Williams PW (1894) Notes on diabetes treated with extract and by grafts of sheep’s pancreas. Br Med J II: 1303–1304
Kelly W, Lillehei RC, Merkel F, Idezaki Y, Goetz FC (1967) Allotransplantation of the pancreas and duodenum along with the kidney in diabetic nephropathy. Surgery 61: 827–837
Dubernard JM, Traeger J, Neyra P, Touraine JL, Tranchant D, Blanc Brunat N (1978) A new method of preparation of segmental pancreatic grafts for transplantation: Trials in Dogs and in Man. Surgery 84: 633–639
Land W, Liebe W, Kuhlaman H, Eberhard E (1980) Simultaneous kidney and pancreas transplantation using prolamine for duct obstruction. Transplant Proc 12: 76–83
Di Carlo V, Chiesa R, Pontiroli AE, Pozza G, Carlucci M, Staudacher C, Secchi A, Cristallo M (1984) Intraductal injection of neoprene to suppress native pancreatic exocrine secretion in humans: clinical and metabolic evaluation. Transplant Proc 16: 736–738
Groth CG, Collste H, Lundgren G, Wilczek H, Klintmaln G, Rindgen O, Gunnarson R, Ostman J (1982) Successful outcome of segmental human pancreatic transplantation with enteric exocrine diversion after modifications in technique. Lancet II: 552–524
Prieto M, Sutherland DER, Goetz FC, Najarian JS (1987) Pancreas transplantation results according to technique of duct management: bladder vs enteric drainage. Surgery 102: 680–691
Sollinger HW, Stratta RJ, Kalayoglu M, Pirsch JD, Beltzer FO (1987) Pancreas transplantation with pancreaticocistostomy and quadruple immunosuppression. Surgery 102: 672–676
Van Hoof JP, Leunissen KLM, Degenaar CP, Menhere CCPA, Beukers EKM, Koostra G (1987) Urine amylase and insulin reserve capacity are valuable tools for diagnosing pancreas allograft rejection. Third ESOT congress, Gothenburg 11–13 June 1987
Severyn W, Olson L, Miller J, Kyriakides G, Rabinovithh A, Flaa C, Mintz D (1982) Studies on the survival of simultaneous canine renal and segmental pancreatic allografts. Transplantation 33: 606–610
Sutherland DER ARROR 1987 ) Pancreas transplantation: an update. In: Alberti KGMM, Krall LP (eds) Diabetes Annual, vol 3. Elsevier, Amsterdam pp 159–188
Piatti PM, Traeger J, Dubernard JM, Bosi E, Finaz J, Mongin Long S, El Yafi S, Secchi A, Pozet N, Monti LD, Pozza G (1985) Hormonal evaluation of immediate pancreatic function in simultaneous kidney plus pancreas transplantation during artificial pancreas monitoring. Transplant Proc 17: 346–348
Pozza G, Traeger J, Dubernard JM, Secchi A, Pontiroli AE, Bosi E, Malik MC, Ruitton A, Blanc N (1983) Endocrine responses of type I diabetic patients following successful pancreas transplantation. Diabetologia 24: 244–248
Secchi A, Pontiroli AE, Bosi E, Piatti PM, Monti LD, Traeger J, Dubernard JM, Gelet A, Pozza G (1985) Effect of different immunosuppressive treatments on the endocrine function of segmental neoprene-injected pancreatic allografts. Transplant Proc 17: 136–140
Pozza G, Bosi E, Secchi A, Piatti PM, Touraine JL, Gelet A, Pontiroli AE, Dubernard JM, Traeger J (1985) Metabolic control of type I diabetes after pancreas transplantation. Br Med J 291: 510–513
Secchi A, Dubernard JM, La Rocca E, Melandri M, Monti L, Touraine JL, Faure JL, Lefrancois N, Pozza G (1988) Metabolic effects of total vs segmental pancreas allotransplantation. First international congress on pancreatic and islet transplantation, abstract 128, 27–29 March 1988, Stockholm
Bosi E, Piatti PM, Secchi A, Monti LD, Traeger J, Dubernard JM, Pozza G (1988) Response of glucagon and insulin secretion to insulin-induced hypoglycemia in type I diabetic patients after pancreatic transplantation. Diabetes Nutr Metab 1: 21–27
Luzi L, Secchi A, Facchini F, Spotti D, Staudacher C, Ferrari G, Martinenghi S, Di Carlo V, Pozza G (1988) Effect of combined kidney and pancreas transplantation on peripheral insulin sensitivity in type I insulin-dependent diabetic uremic subjects (abstract). 7th workshop of the AID SPIT study group, 31. Jan-2. Feb 1988, Igls
Ramsay RC, Goetz FC, Sutherland DER, Mauer SM, Robison LL, Cantrill HL, Knobloch WH, Najarian JS (1988) Progression of diabetic retinopathy after pancreas transplantation for insulin-dependent diabetes mellitus. N Engl J Med 318: 208–214
Bandello F, Vigano C, Secchi A, La Rocca E, Spotti D, Caldara R, Staudacher C, Ferrari G, Carlucci M, Di Carlo V, Brancato R, Pozza G (1988) Diabetic retinopathy in patients submitted to successful kidney and pancreas allotransplantation. First international congress on pancreatic and islet transplantation, abstract 136, 27–29 March 1988, Stockholm
Solders G, Wilczek H, Gunnarsson R, Tyden G, Person A, Groth CG (1987) Effects of combined pancreatic and renal transplantation on diabetic neuropathy: a two-year follow- up study. Lancet II: 1232–1235
Di Carlo V, Secchi A, Staudacher C, Spotti D, Ferrari G, Bosi E, Carlucci M, Martinenghi S, Galardi G, La Rocca E, Torri G, Gallioli G, Valeri R, Perotti V, Pozza G (1988) Pancreas and kidney transplantation in diabetic patients: effects on metabolic control and degenerative complications. First international congress on pancreatic and islet transplantation, abstract 135, 27–29 March 1988, Stockholm
Bohman SO, Tyden G, Wiczek H, Lundgren G, Jaremko G, Gunnarsson R, Ostman J, Groth CG (1984) Prevention of kidney graft diabetic nephropathy by pancreas transplantation in man. Diabetes 34: 306–308
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag · Heidelberg
About this paper
Cite this paper
Pozza, G., Secchi, A. (1990). Metabolic Effects of Pancreas Transplantation in Humans. In: Bretzel, R.G. (eds) Diabetes mellitus. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74610-9_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-74610-9_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-74611-6
Online ISBN: 978-3-642-74610-9
eBook Packages: Springer Book Archive