The Quality and Relevance of Data from Studies in Laboratory Rodents
The rationale for conducting toxicity and carcinogenicity tests of chemicals in laboratory animals assumes that the information obtained will be useful in the prediction of how humans will respond to exposure to the same chemicals. This assumption is reasonably well based in terms of response to short-term high-dose exposure to chemicals, but much less so in terms of later responses to lower doses. As animals grow older, it becomes more and more difficult to distinguish between toxic effects and changes attributable to ageing. Indeed, in many longterm experiments in rodents, most of the differences between exposed and control groups are simply in the incidence and severity of ageing-related diseases. Since the spectra of the most common ageing-related diseases which afflict humans and laboratory rodents are quite different, it is only to be expected that the actual manifestations of chronic toxicity in rodents are quite different from those to be expected in humans.
KeywordsChronic Toxicity Intratracheal Instillation Laboratory Rodent Genotoxic Carcinogenicity Cancer Mortality Data
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