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Epidemiologic Studies of Populations Exposed to Motor Vehicle Exhausts and Polycyclic Aromatic Hydrocarbons

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Assessment of Inhalation Hazards

Part of the book series: ILSI Monographs ((ILSI MONOGRAPHS))

Abstract

Many epidemiologic studies over the last 3 decades have confirmed the association of workplace exposure to polycyclic aromatic hydrocarbons (PAHs) and lung cancer (Lindstedt and Sollenberg 1982). However, most of these studies were of workers with very high exposure from nonmotor vehicle sources (e.g., gas retort and coke oven workers) (Lawther et al. 1965; Lloyd 1971). In addition, exposures in these occupations may also have been qualitatively different from motor vehicle exhausts. More recent epidemiologic studies have focused on workplace exposure to motor vehicle exhaust, with the greatest amount of such work on populations exposed to diesel exhaust. These epidemiologic studies have provided useful data on human risks of lung cancer associated with exposure to diesel exhaust, but have not been useful in evaluating lung cancer risk from gasoline engine exhaust. Population-based studies are limited in their ability to evaluate causal associations of air pollution or PAHs with specific health outcomes, and do not provide useful data for assessing the lung cancer risks associated with motor vehicle exhausts.

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References

  • Commins BT, Waller RE, Lawther PJ (1957) Air pollution in diesel bus garages. Br J Ind Med 14:232–239.

    PubMed  CAS  Google Scholar 

  • Doll R (1978) Atmospheric pollution and lung cancer. Environ Health Perspect 22:23–31.

    Article  PubMed  CAS  Google Scholar 

  • Edling C, Anjou C, Axelson O, Kling H (1987) Mortality among personnel exposed to diesel exhaust. Int Arch Occup Environ Health 59:559–565.

    Article  PubMed  CAS  Google Scholar 

  • Garshick E, Schenker MB, Muñoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, Speizer FE (1987) A case-control study of lung cancer and diesel exhaust exposure in railroad workers. Am Rev Respir Dis 135:1242–1248.

    PubMed  CAS  Google Scholar 

  • Garshick E, Schenker MB, Muñoz A, Segal M, Smith TJ, Woskie SR, Hammond SK, Speizer FE (1988) A retrospective cohort study of lung cancer and diesel exhaust exposure in railroad workers. Am Rev Respir Dis 137:820–825.

    PubMed  CAS  Google Scholar 

  • Gustafssan L, Wall S, Larsson L, Skog B (1986) Mortality and cancer incidence among Swedish dock workers—a retrospective cohort study. Scand J Work Environ Health 12:22–26.

    Article  Google Scholar 

  • Hall NEL, Wynder EL (1984) Diesel exhaust exposure and lung cancer: a case-control study. Environ Res 34:77–86.

    Article  PubMed  CAS  Google Scholar 

  • Hammond EC, Garfinkel L (1980) General air pollution and cancer in the United States. Prev Med 9:206–211.

    Article  PubMed  CAS  Google Scholar 

  • Hammond SK, Smith TJ, Woskie S, Schenker MB, Speizer FE (1985) Characterization of diesel exhaust exposures for a mortality study. In: Cooke M, Dennis AP (eds) Analysis and biological fate: polynuclear aromatic hydrocarbons. Batelle, Columbus, pp 533–541.

    Google Scholar 

  • Hammond SK, Leaderer BP, Roche AC, Schenker M (1987) Collection and analysis of nicotine as a marker for environmental tobacco smoke. Atmos Environ 21:457–462.

    Article  CAS  Google Scholar 

  • Howe GR, Fraser D, Lindsay J, Presnal B, Yu SZ (1983) Cancer mortality (1965–77) in relation to diesel fume and coal exposure in a cohort of retired railway workers. JNCI 70(6): 1015–1019.

    PubMed  CAS  Google Scholar 

  • Ishinishi N, Koizumi A, McClellan RO, Stöber W (eds) (1986) Carcinogenic and mutagenic effects of diesel engine exhaust. Elsevier, Amsterdam.

    Google Scholar 

  • Kado NY, Tesluk SJ, Hammond SK, Woskie SR, Samuels SJ, Schenker MB (1987) Use of a salmonella micro pre-incubation procedure for studying personal exposure to mutagens in environmental tobacco smoke: pilot study of urine and airborne mutagenicity from passive smoking. In: Sandhu S, DeMarini D, Mass M, Moore M, Mumford J (eds) Short-term bioassays in the analysis of complex environmental mixtures, vol V. Plenum, New York, pp 375–390.

    Google Scholar 

  • Lawther PJ, Commins BT, Waller RE (1965) A study of the concentration of polycyclic aromatic hydrocarbons in gas works retort houses. Br J Ind Med 22:13–20.

    PubMed  CAS  Google Scholar 

  • Lindstedt G, Sollenberg J (1982) Polycyclic aromatic hydrocarbons in the occupational environment. Scand J Work Environ Health 8:1–19.

    Article  PubMed  CAS  Google Scholar 

  • Lloyd JW (1971) Long-term mortality study of steelworkers. V. Respiratory cancer in coke plant workers. J Occup Med 13:53–68.

    CAS  Google Scholar 

  • Luepker RV, Smith ML (1978) Mortality in unionized truck drivers. J Occup Med 20(10):677–682.

    PubMed  CAS  Google Scholar 

  • McClellan RO (1986) Health effects of diesel exhaust: a case study in risk assessment. Am Ind Hyg Assoc J 47(1): 1–13.

    Article  PubMed  CAS  Google Scholar 

  • Raffle PAB (1957) The health of the worker. Br J Ind Med 14:73–80.

    PubMed  CAS  Google Scholar 

  • Schenker MB, Speizer FE (dy1979) A retrospective cohort study of diesel exhaust exposure in railroad workers: study design and methodologic issues. In: Pepelko WE, Danner RB, Clarke NA (eds) Health effects of diesel engine emissions. Proceedings of an International Symposium, 3–5 Dec, Cincinnati, pp 1114-1126 (Environmental Protection Agency-600/9-80-57b).

    Google Scholar 

  • Stern FB, Lernen RA, Curtis RA (1981) Exposure of motor vehicle examiners to carbon monoxide: a historical prospective mortality study. Arch Environ Health 36(2):59–66.

    PubMed  CAS  Google Scholar 

  • Waxweiler RJ, Wagoner JK, Archer VE (1973) Mortality of potash workers. J Occup Med 15(6):486–489.

    PubMed  CAS  Google Scholar 

  • Wong D, Mitchell CE, Wolff RK, Mauderly JL, Jeffrey AM (1986) Identification of DNA damage as a result of exposure of rats to diesel engine exhaust. Carcinogenesis 7(9): 1595–1597.

    Article  PubMed  CAS  Google Scholar 

  • Wong O, Morgan RW, Kheifets L, Larson SR, Whorton MD (1985) Mortality among members of a heavy construction equipment operators union with potential exposure to diesel exhaust emissions. Br J Ind Med 42:435–448.

    PubMed  CAS  Google Scholar 

  • Woskie SR, Smith TJ, Hammond SK, Schenker MB, Garshick E, Speizer FE (1988a) Estimation of the diesel exhaust exposures of railroad workers: I. Current exposures. Am J Ind Med 13:381–394.

    Article  PubMed  CAS  Google Scholar 

  • Woskie SR, Smith TJ, Hammond SK, Schenker MB, Garshick E, Speizer FE (1988b) Estimation of the diesel exhaust exposures of railroad workers: II. National and historical exposures. Am J Ind Med 13:395–404.

    Article  PubMed  CAS  Google Scholar 

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© 1989 Springer-Verlag Berlin Heidelberg

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Schenker, M.B. (1989). Epidemiologic Studies of Populations Exposed to Motor Vehicle Exhausts and Polycyclic Aromatic Hydrocarbons. In: Mohr, U., Bates, D.V., Dungworth, D.L., Lee, P.N., McClellan, R.O., Roe, F.J.C. (eds) Assessment of Inhalation Hazards. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74606-2_27

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  • DOI: https://doi.org/10.1007/978-3-642-74606-2_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74608-6

  • Online ISBN: 978-3-642-74606-2

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