Species Differences in Pharmacokinetics, Metabolism, and DNA Binding of Inhaled 1,3-Butadiene
1,3-Butadiene, a major component in synthetic rubber and adiponitrile manufacture, has been found to produce cancer at multiple anatomic sites in two species of experimental animals. In an inhalation bioassay with Sprague-Dawley rats (exposure to 1000 and 8000 ppm for 110 weeks), butadiene affected exclusively organs with endocrine functions and was considered a weak oncogen (Hazleton Laboratories Europe 1981). A recent long-term study with B6C3F1 mice (exposure to 625 and 1200 ppm for 60 weeks) revealed a considerably higher carcinogenic activity (Huff et al. 1985). Target organs were lymphatic tissue, heart, lung mammary gland, and possibly liver.
KeywordsExposure Concentration Epoxide Hydrolase Specific Enzyme Activity Arch Toxicol B6C3F1 Mouse
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