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Immune Responses Against Myelin Basic Protein and/or Galactocerebroside Cross-React with Viruses: Implications for Demyelinating Disease

  • R. S. Fujinami
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 145)

Abstract

It has long been speculated that viruses share cross-reacting determinants with their host self-components. Not until recently could this be directly demonstrated by using monoclonal antibodies (Mabs) and by making direct protein sequence comparisons. This concept of shared common determinants has been the basis for understanding the mechanisms of virus-induced autoimmunity.

Keywords

Myelin Basic Protein Measle Virus Demyelinating Disease Experimental Allergic Encephalomyelitis Molecular Mimicry 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • R. S. Fujinami
    • 1
  1. 1.Department of PathologyUniversity of CaliforniaSan Diego, La JollaUSA

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