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Genes for the Synthesis of Deoxythymidylate Monophosphate in T-Cell Lymphoma-Inducing Herpesviruses of Nonhuman Primates

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Book cover Transforming Proteins of DNA Tumor Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 144))

Abstract

Herpesvirus saimiri (HVS) and herpesvirus ateles (HVA) are T-lymphotropic viruses common in certain New World primates. Both viruses appear not to be pathogenic in their natural host species, squirrel monkeys (Saimiri sciureus) and spider monkeys (Ateles spp.), respectively. However, they can induce rapidly progressing T-cell lymphomas in a wide spectrum of South American monkeys (reviewed in Flecken-stein and Desrosiers 1982), and both viruses are capable of transforming T cells of marmoset monkeys in vitro (Falk et al. 1978; Schirm et al. 1984; Desrosiers et al. 1986). The herpesvirus group is in general highly heterogeneous with respect to the molecular structure of genomic DNA and pathogenic properties.

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References

  • Bankier AT, Dietrich W, Baer R, Barrell BG, Colbère-Garapin F, Fleckenstein B, Bodemer W (1985) Terminal repetitive sequences in herpesvirus saimiri virion DNA. J Virol 55: 133–139

    PubMed  CAS  Google Scholar 

  • Beverly SM, Ellenberger TE, Cordingley JS (1986) Primary structure of the gene encoding the bifunctional dihydrofolate reductase-thymidylate synthase of Leishmania major. Proc Natl Acad Sci USA 83: 2584–2588

    Article  Google Scholar 

  • Bodemer W, Niller HH, Nitsche N, Scholz B, Fleckenstein B (1986) Organization of the thymidylate synthase gene of herpesvirus saimiri. J Virol 60: 114–123

    PubMed  CAS  Google Scholar 

  • Bornkamm GW, Delius H, Fleckenstein B, Werner F-J, Mulder C (1976) Structure of herpesvirus saimiri genomes: arrangement of heavy and light sequences in the M genome. J Virol 19: 154–161

    PubMed  CAS  Google Scholar 

  • Chen M-J, Shimada T, Moulton AD, Cline A, Humphries RK, Maizel J, Nienhuis AW (1984) The functional human dihydrofolate reductase gene. J Biol Chem 259: 3933–3943

    PubMed  CAS  Google Scholar 

  • Desrosiers RC, Bakker A, Kamine J, Falk LA, Hunt RD, King NW (1985) A region of the herpesvirus saimiri genome required for oncogenicity. Science 228: 184–187

    Article  PubMed  CAS  Google Scholar 

  • Desrosiers RC, Silva DP, Waldron LM, Letvin NL (1986) Nononcogenic deletion mutants of herpesvirus saimiri are defective for in vitro immortalization. J Virol 57: 701–705

    PubMed  CAS  Google Scholar 

  • Falk L, Johnson D, Deinhardt F (1978) Transformation of marmoset lymphocytes in vitro with herpesvirus ateles. Int J Cancer 21: 652

    Article  PubMed  CAS  Google Scholar 

  • Fleckenstein B, Desrosiers RC (1982) Herpesvirus saimiri and herpesvirus ateles. In: Roiznan B (ed) The Herpesviruses Vol 1. Plenum, New York, pp 253–332

    Google Scholar 

  • Fleckenstein B, Bornkamm GW, Mulder C, Werner F-J, Daniel MD, Falk LA, Delius H (1978) Herpesvirus ateles DNA and its homology with herpesvirus saimiri nucleic acid J Virol 25: 361–373

    CAS  Google Scholar 

  • Galloway DA, McDougall JK (1983) The oncogenic potential of herpes simplex viruses: evidence for a “hit-and-run” mechanism. Nature 302: 21–24

    Article  PubMed  CAS  Google Scholar 

  • Honess RW, Bodemer W, Cameron KR, Niller H-H, Fleckenstein B, Randall RE (1986) The A+ T-rich genome of herpesvirus saimiri contains a highly conserved gene for thymidylate synthase. Proc Natl Acad Sci USA 83: 3604–3608

    Article  PubMed  CAS  Google Scholar 

  • Kamine J, Bakker A, Desrosiers RC (1984) Mapping of RNA transcribed from a region of the herpesvirus saimiri genome required for oncogenicity. J Virol 52: 532–540

    PubMed  CAS  Google Scholar 

  • Kaschka-Dierich C, Falk L, Bjursell G, Adams A, Lindahl T (1977) Human lymphoblastoid cell lines derived from individuals without lymphoproliferative disease contain the same latent forms of Epstein-Barr virus DNA as those found in tumor cells. Int J Cancer 20: 173–180

    Article  PubMed  CAS  Google Scholar 

  • Kaschka-Dierich C, Werner FJ, Bauer I, Fleckenstein B (1982) Structure of nonintegrated, circular herpesvirus saimiri and herpesvirus ateles genomes in tumor cell lines and in vitro-trans-formed cells. J Virol 44: 295–310

    PubMed  CAS  Google Scholar 

  • Koomey JM, Mulder C, Burghoff RL, Fleckenstein B, Desrosiers RC (1984) Deletion of DNA sequences in a nononcogenic variant of herpesvirus saimiri 11. J Virol 50: 662–665

    PubMed  CAS  Google Scholar 

  • Laufs R, Fleckenstein B (1973) Susceptibility to Herpesvirus saimiri and antibody development in Old and New World monkeys. Med Microbiol Immunol (Berl) 158: 227–236

    Article  CAS  Google Scholar 

  • Masters JN, Attardi G (1983) The nucleotide sequence of the cDNA coding for the human di-hydrofolic acid reductase. Gene 21: 59–63

    Article  PubMed  CAS  Google Scholar 

  • Medveczky P, Szomolanyi E, Desrosiers RC, Mulder C (1984) Classification of herpesvirus saimiri into three groups based on extreme variation in a DNA region required for oncogenicity. J Virol 52: 938–944

    PubMed  CAS  Google Scholar 

  • Purohit S, Mathews CK (1984) Nucleotide sequence reveals overlap between T4 phase genes encoding dihydrofolate reductase and thymidylate synthase. J Biol Chem 259: 6261–6266

    PubMed  CAS  Google Scholar 

  • Richter J, Puchtler I, Fleckenstein B (1988) The thymidylate synthase gene of herpesvirus ateles. J Virol 62: 3530–3535

    PubMed  CAS  Google Scholar 

  • Schirm S, Müller I, Desrosiers RC, Fleckenstein B (1984) Herpesvirus saimiri DNA in a lymphoid cell line established by in vitro transformation. J Virol 49: 938–946

    PubMed  CAS  Google Scholar 

  • Stamminger T, Honess RW, Young DF, Bodemer W, Blair ED, Fleckenstein B (1987) Organization of terminal reiterations in the virion DNA of herpesvirus saimiri. J Gen Virol 68: 1049–1066

    Article  PubMed  CAS  Google Scholar 

  • Szomolanyi E, Medveczky P, Mulder C (1987) In vitro immortalization of marmoset cells with three subgroups of herpesvirus saimiri. J Virol 61: 3485–3490

    PubMed  CAS  Google Scholar 

  • Takeishi K, Kaneda S, Ayusawa D, Shimizu K, Gotoh O, Seno T (1985) Nucleotide sequence of a functional cDNA for human thymidylate synthase. Nucleic Acid Res 13: 2035–2043

    Article  PubMed  CAS  Google Scholar 

  • Thompson R, Honess RW, Taylor L, Morran J, Davison AJ (1987) Varicella-zoster virus specifies a thymidylate synthetase. J Gen Virol 68: 1449–1455

    Article  PubMed  CAS  Google Scholar 

  • Trimble JJ, Murthy SCS, Bakker A, Grassmann R, Desrosiers RC (1988) A gene for dihydro-folate reductase in a herpesvirus. Science 239: 1145–1147

    Article  PubMed  CAS  Google Scholar 

  • Werner F-J, Bornkamm GW, Fleckenstein B (1977) Episomal viral DNA in a herpesvirus saimiri-transformed lymphoid cell line. J Virol 22: 794

    PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Institut für Klinische und Molekulare Virologie der Universität Erlange-Nürnberg, 8520, Erlangen, Deutschland

    B. Biesinger, R. Grassmann & B. Fleckenstein

  2. New England Regional Primate Research Center, Harvard Medical School, Southborough, MA, 01772, USA

    S. C. S. Murthy, J. Trimble & R. C. Desrosiers

Authors
  1. B. Biesinger
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  2. R. Grassmann
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  3. B. Fleckenstein
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  4. S. C. S. Murthy
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  5. J. Trimble
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  6. R. C. Desrosiers
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Editor information

Editors and Affiliations

  1. Fakultät für Biologie, Universität Konstanz, D-7750, Konstanz, Germany

    Rolf Knippers Dr.

  2. Department of Biology, Princeton University, Princeton, N.J., 08544-1014, USA

    Arnold J. Levine Ph.D.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Biesinger, B., Grassmann, R., Fleckenstein, B., Murthy, S.C.S., Trimble, J., Desrosiers, R.C. (1989). Genes for the Synthesis of Deoxythymidylate Monophosphate in T-Cell Lymphoma-Inducing Herpesviruses of Nonhuman Primates. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_30

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  • DOI: https://doi.org/10.1007/978-3-642-74578-2_30

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74580-5

  • Online ISBN: 978-3-642-74578-2

  • eBook Packages: Springer Book Archive

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