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Two Independently Transforming Functions of Human Papillomavirus 8

  • Conference paper
Transforming Proteins of DNA Tumor Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 144))

Abstract

The human papillomaviruses (HPVs) cause a variety of benign tumors of the skin and mucosa and are of particular medical interest due to their association with human cancers (Pfister 1984). A large group of HPVs is associated with epidermodysplasia verruciformis (ev), a lifelong disease, which is characterized by disseminated flat warts and macular skin lesions that develop into squamous cell carcinomas in 30%-50% of the sufferers (Orth 1987). More than 90% of these cancers are persistently infected with HPV-5 or HPV-8, which were also discovered in skin carcinomas of immunosuppressed transplant recipients (Bunney et al. 1987). These HPV types are therefore assumed to represent particular risk factors for the development of skin cancer.

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Author information

Authors and Affiliations

  1. Institut für Klinische und Molekulare Virologie, Universität Erlangen—Nürnberg, Erlangen, Germany

    T. Iftner, P. G. Fuchs & H. Pfister

Authors
  1. T. Iftner
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  2. P. G. Fuchs
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  3. H. Pfister
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Editor information

Editors and Affiliations

  1. Fakultät für Biologie, Universität Konstanz, D-7750, Konstanz, Germany

    Rolf Knippers Dr.

  2. Department of Biology, Princeton University, Princeton, N.J., 08544-1014, USA

    Arnold J. Levine Ph.D.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Iftner, T., Fuchs, P.G., Pfister, H. (1989). Two Independently Transforming Functions of Human Papillomavirus 8. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_20

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  • DOI: https://doi.org/10.1007/978-3-642-74578-2_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74580-5

  • Online ISBN: 978-3-642-74578-2

  • eBook Packages: Springer Book Archive

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