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Functional and Sequence Similarities Between HPV16 E7 and Adenovirus E1A

  • Conference paper
Transforming Proteins of DNA Tumor Viruses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 144))

Abstract

Recent molecular and epidemiological data have established a strong association between certain human papillomaviruses (HPVs) and some types of human anogenital cancers. More than a dozen different HPV types have now been isolated from epithelial tumors of the genital region. In general, benign genital condyloma acuminata have been associated with the presence of HPV types 6 and 11, whe reas precancerous lesions such as moderate to severe cervical dysplasia and carcinoma in situ, as well as invasive cervical carcinoma, have been associated with HPV types 16, 18, 31, 33, and 35 (zur Hausen and Schneider 1987). Of the HPVs which have been associated with anogenital malignancies, HPV-16 has been detected most frequently (> 60%) in biopsies from cervical carcinoma.

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Authors and Affiliations

  1. Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland, 20892, USA

    W. C. Phelps, C. L. Yee, K. Münger & P. M. Howley

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  1. W. C. Phelps
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  2. C. L. Yee
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  3. K. Münger
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  4. P. M. Howley
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Editors and Affiliations

  1. Fakultät für Biologie, Universität Konstanz, D-7750, Konstanz, Germany

    Rolf Knippers Dr.

  2. Department of Biology, Princeton University, Princeton, N.J., 08544-1014, USA

    Arnold J. Levine Ph.D.

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© 1989 Springer-Verlag Berlin · Heidelberg

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Phelps, W.C., Yee, C.L., Münger, K., Howley, P.M. (1989). Functional and Sequence Similarities Between HPV16 E7 and Adenovirus E1A. In: Knippers, R., Levine, A.J. (eds) Transforming Proteins of DNA Tumor Viruses. Current Topics in Microbiology and Immunology, vol 144. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74578-2_19

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  • DOI: https://doi.org/10.1007/978-3-642-74578-2_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74580-5

  • Online ISBN: 978-3-642-74578-2

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