• Rolf Knippers
  • Arnold J. Levine
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 144)


More than 30 years ago an endemic mouse virus was discovered that induced tumors in newborn animals. Tumors developed in many different organs of the infected mouse, hence the name Polyomavirus. The virus also transforms cultured rodent embryo cells, which give rise to tumors when injected into susceptible animals (Tooze 1981).


Infected Mouse Transformation Function Simian Virus Established Cell Susceptible Animal 
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  1. Fried M, Prives C (1986) The biology of simian virus 40 and polyoma virus. Cancer Cells 4: 1–16Google Scholar
  2. Tooze J (ed) (1981) DNA tumor viruses. Molecular biology of tumor viruses, pt 2. Cold Spring Harbor Laboratory, Cold Spring HaborGoogle Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • Rolf Knippers
    • 1
  • Arnold J. Levine
    • 2
  1. 1.Fakultät für BiologieUniversität KonstanzKonstanzGermany
  2. 2.Department of BiologyPrinceton UniversityPrincetonUSA

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