The Biological Activity of Early SV40 Antisense RNA and DNA Molecules

  • M. Graessmann
  • A. Graessmann
Conference paper
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 144)


It is of basic and applied scientific interest to develop reliable techniques which allow the down regulation of single genes either in isolated cells or in cells of an intact organism. Such an approach should give us a more detailed insight into the particular role of single genes for growth and cell differentiation and offer us the possibility to cure cells in cases in which overproduction of a specific protein is the reason for the cellular malfunction. One promising method to decrease selectively the expression rate of either endogeneous or transgenes at the post-transcriptional level is the use of antisense RNA and DNA molecules.


Thymidine Kinase Antisense Orientation Antisense Molecule Thymidine Kinase Expression Mammalian Tissue Culture Cell 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • M. Graessmann
    • 1
  • A. Graessmann
    • 1
  1. 1.Institut für Molekularbiologie und BiochemieFreie Universität BerlinBerlin 33Germany

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