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Cone Shell Toxins and the Mechanisms of Their Pharmacological Action

  • Conference paper
Bioorganic Marine Chemistry

Part of the book series: Bioorganic Marine Chemistry ((BMC,volume 3))

Abstract

The present review mainly focusses on our recent findings on the structure and mechanism of action of bioactive compounds from cone shells. Cone shells are divided into three groups according to their major prey organisms: worm-eating (vermivorous), shellfish-eating (molluscivorous), and fish-eating (piscivorous). Each species has a venom that reflects the dominant target animals. Various kinds of toxins with novel pharmacological properties have been isolated from cone shell venoms: Conus geographus (geographutoxins I and II, α-, μ-, and ω-conotoxins), C. striatus (striatoxin), C. magus (myotoxin MgTX), C. eburneus (eburnetoxin), C. tessulatus (tessulatoxin), C. textile (arachidonic acid). We also discuss the growing importance of these stinging toxins as tools for studies aimed at elucidating the function of ion channels.

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Author information

Authors and Affiliations

  1. Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo, 194, Japan

    Yasushi Ohizumi

Authors
  1. Masaki Kobayashi
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  2. Jun’ichi Kobayashi
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  3. Yasushi Ohizumi
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Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii, 96822, USA

    Paul J. Scheuer

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© 1989 Springer-Verlag Berlin Heidelberg

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Kobayashi, M., Kobayashi, J., Ohizumi, Y. (1989). Cone Shell Toxins and the Mechanisms of Their Pharmacological Action. In: Scheuer, P.J. (eds) Bioorganic Marine Chemistry. Bioorganic Marine Chemistry, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74560-7_3

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  • DOI: https://doi.org/10.1007/978-3-642-74560-7_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74562-1

  • Online ISBN: 978-3-642-74560-7

  • eBook Packages: Springer Book Archive

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