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Sperm-Activating Peptides from Sea Urchin Egg Jelly

  • Conference paper
Bioorganic Marine Chemistry

Part of the book series: Bioorganic Marine Chemistry ((BMC,volume 3))

Abstract

Speract (Gly-Phe-Asp-Leu-Asn-Gly-Gly-Gly-Val-Gly) and ten of its derivatives obtained from the egg jelly of sea urchins, Order Echinoida, stimulate the respiration and motility of spermatozoa of sea urchins belonging to the same order. Resact (Cys-Val-Thr-Gly-Ala-Pro-Gly-Cys-Val-Gly-Gly-Gly-Arg-LeuNH2) and mosact (Asp-Ser-Asp-Ser-Ala-Gln-Asn-Leu-Ile-Gly) and two of its derivatives obtained from Arbacia punctulata eggs, Order Arbacioida, and Clypeaster japonicus eggs, Order Clypeasteroida, also stimulate the metabolism and motility of respective sea urchin spermatozoa. Two other peptides (Gly-(X)-Pro-(X)-Gly-Gly-Ala-Val- and ) were isolated from the egg jelly of the sea urchin Diadema setosum, Order Diadematoida. These are specific for Diadema setosum spermatozoa. Early biochemical responses of the spermatozoa to the egg jelly peptides include at a net hydrogen ion efflux and elevations of cyclic AMP and cyclic GMP concentrations. In additoin, a major sperm plasma protein is modified in response to the peptides such that its apparent molecular weight is lowered with exception of the response of Glyptocidaris crenularis spermatozoa to alloresact (Lys-Leu-Cys-Pro-Gly-Gly-Asn-Cys-Val). The plasma membrane protein appears to be the enzyme guanylate cyclase. Resact acts as a chemoattractant for Arbacia punctulata and speract promotes the acrosome reaction of Hemicentrotus pulcherrimus spermatozoa as a cofactor.

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Author information

Authors and Affiliations

  1. Noto Marine Laboratory, Kanazawa University, Ogi, Uchiura, Ishikawa, 927-05, Japan

    Norio Suzuki

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  1. Norio Suzuki
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Editor information

Editors and Affiliations

  1. Department of Chemistry, University of Hawaii at Manoa, 2545 The Mall, Honolulu, Hawaii, 96822, USA

    Paul J. Scheuer

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© 1989 Springer-Verlag Berlin Heidelberg

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Suzuki, N. (1989). Sperm-Activating Peptides from Sea Urchin Egg Jelly. In: Scheuer, P.J. (eds) Bioorganic Marine Chemistry. Bioorganic Marine Chemistry, vol 3. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74560-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-74560-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74562-1

  • Online ISBN: 978-3-642-74560-7

  • eBook Packages: Springer Book Archive

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