Abstract
It has long been assumed that equilibrium models of cellular excitation that focus on depolarization of the membrane potential and associated massive changes in ionic equilibria across the cell membrane also offer an adequate basis for an understanding of the first events in cell membrane transductive coupling of molecular and electrochemical stimuli at the cell surface. For nervous tissue, it has been generally accepted that the Hodgkin-Huxley (1952) model appropriately describes both sequence and energetics of excitatory events. However, this brilliant thesis from relatively limited biological data was originally offered only in the context of a mathematical description of major perturbations in Na+ and K+ ionic equilibria that occur at a certain epoch in the course of excitation in giant nerve fibers of the squid.
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Adey, W.R. (1989). Cell Membranes, Electromagnetic Fields, and Intercellular Communication. In: Başar, E., Bullock, T.H. (eds) Brain Dynamics. Springer Series in Brain Dynamics, vol 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74557-7_4
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DOI: https://doi.org/10.1007/978-3-642-74557-7_4
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