The Clinical Use of P300 Cartography in Diseases with Disturbed Cognitive Processing of the Brain
Until recently evoked potentials (EPs) were recorded mainly with few electrodes. For evaluation of information processing in normals and patients, latency measurements were usually performed. This procedure proved very valuable when early auditory evoked potentials (EAEPs) were applied to evaluate hearing function and to localize lesions in the lower auditory pathway (Starr and Achor 1975; Stockard and Rossiter 1977; Maurer et al. 1979, 1982). Topodiagnosis in neurootology became possible by virtue of the fact that EAEPs originate in well defined structures along the auditory nerve and in the brain stem (Möller et al. 1981; Maurer and Mika 1983). It is acknowledged that the generator site of wave I is the auditory nerve while that of waves II to V is the proximal part of the auditory nerve (II) and adjacent portions of the brain stem such as the lower pons (wave III), upper pons (wave IV), and midbrain (wave V). The generator sites of later waves, such as AEPs of middle and late latency, could not be determined as accurately as in the case of EAEPs, with the consequence that the diagnostic value of the late waves has remained limited until now.
KeywordsDepression Dementia Schizophrenia Neurol Kelly
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