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Brain Dynamics pp 420-428 | Cite as

The Clinical Use of P300 Cartography in Diseases with Disturbed Cognitive Processing of the Brain

  • K. Maurer
Conference paper
Part of the Springer Series in Brain Dynamics book series (SSBD, volume 2)

Abstract

Until recently evoked potentials (EPs) were recorded mainly with few electrodes. For evaluation of information processing in normals and patients, latency measurements were usually performed. This procedure proved very valuable when early auditory evoked potentials (EAEPs) were applied to evaluate hearing function and to localize lesions in the lower auditory pathway (Starr and Achor 1975; Stockard and Rossiter 1977; Maurer et al. 1979, 1982). Topodiagnosis in neurootology became possible by virtue of the fact that EAEPs originate in well defined structures along the auditory nerve and in the brain stem (Möller et al. 1981; Maurer and Mika 1983). It is acknowledged that the generator site of wave I is the auditory nerve while that of waves II to V is the proximal part of the auditory nerve (II) and adjacent portions of the brain stem such as the lower pons (wave III), upper pons (wave IV), and midbrain (wave V). The generator sites of later waves, such as AEPs of middle and late latency, could not be determined as accurately as in the case of EAEPs, with the consequence that the diagnostic value of the late waves has remained limited until now.

Keywords

Auditory Nerve P300 Amplitude Late Wave Late Latency Lower Pons 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Ball MJ, Hachinski V, Fox A, Kirshen AJ, Fisman M, Blume W, Krai VA, Fox H (1987) A new definition of Alzheimer’s disease: a hippocampal dementia. Lancet 5: 14–16Google Scholar
  2. Bogerts B, Meertz E, Schonfeldt-Bausch R (1985) Basal ganglia and limbic system pathology in schizophrenia. Arch Gen Psychiatry 42: 784–791PubMedCrossRefGoogle Scholar
  3. Brun A, Gustafson L (1976) Distribution of cerebral degeneration in Alzheimer’s disease. Arch Psychiatr Neurol 223: 15–33CrossRefGoogle Scholar
  4. Duffy FH, Burchfiel JL, Lombroso CT (1979) Brain electrical activity mapping (BEAM): a method for extending the clinical utility of EEG and evoked potentials data. Ann Neurol 5: 309–321PubMedCrossRefGoogle Scholar
  5. Farkas T, Wolf AP, Jaeger J, Brodie JD, Christman DR, Fowler JS (1984) Regional brain glucose metabolism in chronic schizophrenia. Arch Gen Psychiatry 41: 293–300PubMedCrossRefGoogle Scholar
  6. Halgren E, Squires NK, Wilson CL, Crandell PH (1982) Brain generators of evoked potentials: the late (endogenous) components. Bull Los Angeles Neurol Soc 47: 108–123PubMedGoogle Scholar
  7. Ingwar DH, Franzen G (1974) Abnormalities of cerebral blood flow distribution in patients with chronic schizophrenia. Acta Psychiatr Scand 40: 425–462CrossRefGoogle Scholar
  8. Itil TM (1978) Qualitative und quantitative EEG-Befunde bei Schizophrenien. Z EEG EMG 9: 1–13Google Scholar
  9. Karson CN, Coppola R, Morihisa JM, Weinberger DR (1987) Computed electroencephalographic activity mapping in schizophrenia. Arch Gen Psychiatry 44: 514–517PubMedCrossRefGoogle Scholar
  10. Maurer K, Dierks T (1987) Brain Mapping—topographische Darstellung des EEG und der evozierten Potentiale in Psychiatrie und Neurologie. Z EEG EMG 18: 1–9Google Scholar
  11. Maurer K, Mika H (1983) Early auditory evoked potentials (EAEPs) in the rabbit. Normative data and effects of lesions in the cerebello-pontine angle. Electroencephalogr Clin Neurophysiol 55: 586–593PubMedCrossRefGoogle Scholar
  12. Maurer K, Leitner H, Schäfer E, Hopf HC (1979) Frühe akustisch evozierte Potentiale, ausgelöst durch einen sinusförmigen Reiz. Dtsch Med Wochenschr 104: 546–550PubMedCrossRefGoogle Scholar
  13. Maurer K, Leitner H, Schäfer E (1982) Akustisch evozierte Potentiale. Enke, StuttgartGoogle Scholar
  14. Möller AR, Jannetta PJ, Möller BM (1981) Neural generators of brainstem evoked potentials. Results from human intracranial recordings. Ann Otol 90: 591–599Google Scholar
  15. Morstyn R, Duffy FH, McCarley RW (1983) Altered topography of EEG spectral content in schizophrenia. Electroencephalogr Clin Neurophysiol 56: 263–271PubMedCrossRefGoogle Scholar
  16. Okada YC, Kaufman L, Williamson SJ (1983) The hippocampal formation as a source of slow endogenous potentials. Electroencephalogr Clin Neurophysiol 55: 417–426PubMedCrossRefGoogle Scholar
  17. Pfefferbaum A, Wenegrat BG, Ford JW, Roth WT, Kopell BS (1984) Clinical application of the P3 component of event-related potentials. II. Dementia, depression and schizophrenia. Electroencephalogr Clin Neurophysiol 59: 104–124PubMedCrossRefGoogle Scholar
  18. Roth WT, Pfefferbaum A, Kelly AF, Berger PA, Kopell BS (1981) Auditory event-related potentials in schizophrenia and depression. Psychiatr Res 4: 199–212CrossRefGoogle Scholar
  19. Starr A, Achor LJ (1975) Auditory brainstem responses in neurological disease. Arch Neurol 32: 761–768PubMedCrossRefGoogle Scholar
  20. Stigsby B, Johannesson G, Ingwar D (1981) Regional EEG-analysis and regional cerebral blood flow in Alzheimer’s disease. Electroencephalogr Clin Neurophysiol 51: 537–547PubMedCrossRefGoogle Scholar
  21. Stockard J J, Rossiter VS (1977) Clinical and pathologic correlates of brainstem auditory response abnormalities. Neurology (Minneap) 27: 316–325Google Scholar
  22. Sutton S, Braren M, Zubin J, John ER (1965) Evoked potential correlates of stimulus uncertainty. Science 150: 1187–1188PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • K. Maurer

There are no affiliations available

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