Abstract
The pantropical genus Tabernaemontana comprises about 120 species. Many species are used in traditional medicine. The most often reported uses are as an antimicrobial agent, curing diseases caused by parasites and protozoa, against warts, as analgetic, as stimulant and as febrifuge. Despite these activities, until recently little work has been done on the isolation of active compounds. Most of the work on this genus was pure phytochemical: the isolation of indole alkaloids. For extensive reviews the reader is referred to van Beek et al. (1984) and Danieli and Palmisano (1986).
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References
Van Beek TA, Verpoorte R, Baerheim Svendsen A, Leeuwenberg AJM, Bisset NG (1984) Tabernaemontana L. (Apocynaceae): a review of its taxonomy, phytochemistry, ethnobotany and pharmacology. J Ethnopharmacol 10:1–156
Van Beek TA, Verpoorte R, Baerheim Svendsen A, Fokkens R (1985) Antimicrobially active alkaloids from Tabernaemontana chippii. J Nat Prod 48:400–423
Danieli B, Palmisano G (1986) Alkaloids from Tabernaemontana. In: Brossi A (ed) The alkaloids. Academic Press, New York London, pp 1–55
Eilert U, De Luca V, Constabel F, Kurz WGW (1987) Elicitor mediated induction of tryptophan decarboxylase and strictosidine synthase in cell suspension cultures of Catharanthus roseus. Arch Biochem Biophys 254:491–497
Van der Heijden R, Brouwer RL, Verpoorte R, Wijnsma R, van Beek TA, Harkes PAA, Baerheim Svendsen A (1986a) Indole alkaloids from Tabernaemontana elegans (whole plant). Phytochemistry 25:144–147
Van der Heijden R, Brouwer RL, Verpoorte R, Wijnsma R, van Beek TA, Harkes PAA, Baerheim Svendsen A (1986b) Indole alkaloids from a callus culture of Tabernaemontana elegans. Phytochemistry 25:843
Van der Heijden R, Wijnsma R, Verpoorte R, Harkes PAA, Baerheim Svendsen A (1986c) The influence of nutrient media, auxins and cytokinins on the initiation of alkaloid producing callus on leaf expiants of eight species of Tabernaemontana. Fitoterapia 57:415–421
Van der Heijden R, Lamping PJ, Out PP, Wijnsma R, Verpoorte R (1987a) High-performance liquid chromatographic determination of indole alkaloids in a suspension culture of Tabernaemontana divaricata. J Chromatogr 396:287–295
Van der Heijden R, Hermans-Lokkerbol A, Verpoorte R, Baerheim Svendsen A (1987b) Phar-macognostical studies on Tabernaemontana XX. Ion-pair droplet counter-current chromatography of indole alkaloids from suspension cultures. J Chromatogr 396:410–415
Van der Heijden R, Schripsema J, Harkes PAA, Verpoorte R (1987c) Alkaloid production by plant cell cultures of Tabernaemontana species. In: Neijssel OM, van der Meer RR, Luyben KChAM (eds) Proc 4th Eur Congr Biotechnology 1987, vol 2. Elsevier, Amsterdam, pp 397–398
Van der Heijden R, Verheij ER, Schripsema J, Baerheim Svendsen A, Verpoorte R, Harkes PAA (1988a) Induction of triterpene biosynthesis by elicitors in suspension cultures of Tabernaemontana species. Plant Cell Rep 7:51–54
Van der Heijden R, van der Graaf GM, Pennings EJM, Verpoorte R (1988b) Formation and degradation of some aspidospermatan indole alkaloids in suspension cultures of Tabernaemontana divaricata. (submitted)
Van der Heijden R, Verpoorte R, Harkes PAA (1988c) Effects of elicitors on the production of secondary metabolites in plant cell cultures of Cinchona, Rubia, Morinda and Tabernaemontana. In: Rhodes MJC, Robins RJ (eds) Proc IAPTC-Symp, Norwich, pp 217–224
Van der Heijden R, Hermans-Lokkerbol A, de Kool LPJ, Lamping PJ, Harkes PAA, Verpoorte R (1988d) Accumulation of indole alkaloids in a suspension culture of Tabernaemontana divaricata. Planta Med 54:393–397
Van der Heijden R, Verpoorte R, Harkes PAA (1988e) Secondary metabolites in cell and tissue cultures of species belonging to the tribe Tabernaemontanae (Apocynaceae). In: Bajaj YPS (ed) Biotechnology in forestry and agriculture. Vol 7. Medicinal and aromatic plants, part 2. Springer, Berlin Heidelberg New York Tokyo pp 506–523
Knobloch KH, Bast G, Berlin J (1982) Medium-and light-induced formation of serpentine and anthocyanins in cell suspension cultures of Catharanthus roseus. Phytochemistry 21:591–594
Morris P (1986) Regulation of product synthesis in cell cultures of Catharanthus roseus. II. Comparison of production media. Planta Med 52:121–126
Pawelka KH, Stoeckigt (1983) Indole alkaloids from cell suspension cultures of Tabernaemontana divaricata and Tabernanthe iboga. Plant Cell Rep 2:105–107
Pennings EJM, Hegger I, van der Heijden R, Duine JA, Verpoorte R (1987) Assay of tryptophan decarboxylase from plant cell cultures. Anal Biochem 165:133–136
Pennings EJM, van der Heijden R, van den Bosch RA, van der Leer T, Verpoorte R (1988) Rapid assay of tryptophan decarboxylase from plant cell cultures. In: Rhodes MJC, Robins RJ (eds) Proc IAPTC-Symp, Norwich, pp 79–92
Pennings EJM, van den Bosch RA, van der Heijden R, Stevens LH, Duine JA, Verpoorte R (1989) Assay of strictosidine synthase from plant cell cultures by HPLC. Anal Biochem 176:412–415
Verpoorte R (1987) Antimicrobially active alkaloids. In: Kramer A, Weuffen W, Krasilnikov AP, Groeschel D, Bulke E, Rehn D (eds) Handbuch der Antiseptik, vol 2, pt 3. Volk und Gesundheit, Berlin, pp 385–422
Zenk MH, El-Shagi H, Arens H, Stoeckigt J, Weiler EW, Deus B (1977) Formation of the indole alkaloids serpentine and ajmalicine in cell suspension cultures of Catharanthus roseus. In: Barz W, Reinhard W, Zenk MH (eds) Plant tissue culture and its biotechnological application. Springer, Berlin Heidelberg New York, pp 27–43
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Verpoorte, R. et al. (1989). Secondary Metabolites in Cell Cultures of Tabernaemontana Species. In: Kurz, W.G.W. (eds) Primary and Secondary Metabolism of Plant Cell Cultures II. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74551-5_16
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DOI: https://doi.org/10.1007/978-3-642-74551-5_16
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