On the Mechanism of Transport by the Uncoupling Protein from Brown Adipose Tissue Mitochondria
The uncoupling protein enables brown adipose tissue mitochondria to uncouple respiration from ATP synthesis under thermogenic conditions by catalyzing re-entry of protons extruded by the respiratory chain. Two ligands, purine nucleotides and fatty acids, interact specifically with the protein to modulate its transport activity (for review see Rial & Nicholls, 1987).
KeywordsBrown Adipose Tissue Proton Conductance Uncouple Protein Brown Adipocyte Purine Nucleotide
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