Skip to main content

Modulation of the Mitochondrial Channel VDAC by a Variety of Agents

  • Conference paper
Anion Carriers of Mitochondrial Membranes

Abstract

A major difference between prokaryotes and eukaryotes is the extensive use of intracellular membranous organelles, by eukaryotes, to compartmentalize metabolic processes. The full implications of this compartmentation will probably not be appreciated for some time. However, it is clear that this compartmentation poses barriers to the movement of metabolites from one compartment to another. Transport systems both overcome these barriers and provide a means for regulating the flux of metabolites and thus the rate and direction of metabolic processes.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Colombini M (1979) A candidate for the permeability pathway of the outer mitochondrial membrane. Nature 279:643–645

    Article  PubMed  CAS  Google Scholar 

  • Colombini M (1980) Structure and mode of action of a voltage dependent anion-selective channel (VDAC) located in the outer mitochondrial membrane. Ann N Y Acad Sci (USA) 341:552–563

    Article  CAS  Google Scholar 

  • Colombini M (1986) Voltage gating in VDAC: toward a molecular mechanism. In: Miller C (ed) Ion Channel Reconstitution. Plenum Press, New York, p 533

    Google Scholar 

  • Colombini M, Choh LY, Tung J, Konig T (1987) The mitochondrial outer membrane channel, VDAC, is regulated by a synthetic polyanion. Biochim Biophys Acta 905:279–286

    Article  PubMed  CAS  Google Scholar 

  • Doring C, Colombini M (1985) Voltage dependence and ion selectivity of the mitochondrial channel, VDAC, are modified by succinic anhydride. J Membr Biol 83:81–86

    Article  PubMed  CAS  Google Scholar 

  • Forte M, Guy HR, Mannella CA (1987) Molecular genetics of the VDAC ion channel: structural model and sequence analysis. J Bioenerg Biomemb 19:341–350

    Article  CAS  Google Scholar 

  • Gellerich FN, Kunz W (1987) Cause and consequences of dynamic compartmentation of adenine nucleotides in the mitochondrial intermembrane space in respect to exchange of energy rich phosphates between cytosol and mitochondria. Biomed Biochim Acta 46:S545–S548

    PubMed  CAS  Google Scholar 

  • Holden MJ, Colombini M (1988) A cellular protein modulates the behavior of the mitochondrial outer membrane channel, VDAC. Biophys J 53:266a

    Google Scholar 

  • Kleene R, Pfanner N, Link TA, Sebald W, Neupert W, Tropschug M (1987) Mitochondrial porin of N. crossa: cDNA cloning, in vitro expression and import into mitochondria. EMBO J 6:2627–2633

    PubMed  CAS  Google Scholar 

  • Mangan PS, Colombini M (1987) Ultrasteep voltage dependence in a membrane channel. Proc Natl Acad Sci (USA) 84:4896–4900

    Article  CAS  Google Scholar 

  • Mannella CA, Capolongo N, Berkowitz R (1986) Correlation between outer-membrane lysis and susceptibility of mitochondria to inhibition by adriamycin and polyammes. Biochim Biophys Acta 848:312–316

    Article  PubMed  CAS  Google Scholar 

  • Mannella CA, Tedeschi H (1987) Importance of the mitochondrial outer membrane channel as a model biological channel. J Bioenerg Biomemb 19:305–308

    Article  CAS  Google Scholar 

  • Mini-Review Series (1987) Biological channels: focus on the outer mitochondrial membrane. J Bioenerg Biomemb 19:305–358

    Article  Google Scholar 

  • Smack D, Colombini M (1985) Voltage-dependent channels found in the membrane fraction of corn mitochondria. Plant Physiol 79:1094–1097

    Article  PubMed  CAS  Google Scholar 

  • Schein SJ, Colombini M, Finkelstein A (1976) Reconstitution in planar lipid bilayers of a voltage-dependent anion-selective channel obtained from Paramecium mitochondria. J Membr Biol 30:99–120

    Article  PubMed  CAS  Google Scholar 

  • Zimmerberg J, Parsegian VA (1986) Polymer inaccessible volume changes during opening and closing of a voltage-dependent ionic channel. Nature 323:36–39

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1989 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Colombini, M., Holden, M.J., Mangan, P.S. (1989). Modulation of the Mitochondrial Channel VDAC by a Variety of Agents. In: Azzi, A., Nałęz, K.A., Nałęcz, M.J., Wojtczak, L. (eds) Anion Carriers of Mitochondrial Membranes. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-74539-3_17

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-74539-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-74541-6

  • Online ISBN: 978-3-642-74539-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics