Kinetic Mechanisms of the Adenylic and the Oxoglutaric Carriers: a Comparison

  • F. E. Sluse
  • C. M. Sluse-Goffart
  • C. Duyckaerts

Abstract

Translocations by exchange through membranes must obey to one of the two general types of mechanisms: the ping-pong mechanism and the sequential mechanism.

Keywords

Adenine Succinate Pyrophosphate Malonate Controle 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Barbour RL, Chan SHP (1981) Characterization of the kinetics and mechanism of the mitochondrial ADP-ATP carrier. J Biol Chem 256:1940–1948PubMedGoogle Scholar
  2. Dierks T, Krämer R (1988) Reaction mechanism of the reconstituted aspartate/glutamate antiporter from mitochondria. Reversible switching to uniport function. In: Azzi A, Nałęcz KA, Nałęcz MJ, Wojtczak L (eds) The Anion Carriers of the Mitochondrial Membranes. Springer-Verlag Heidelberg, pp 99-110Google Scholar
  3. Duyckaerts C, Sluse-Goffart CM, Fux JP, Sluse FE, Liébecq C (1980) Kinetic mechanism of the exchanges catalysed by the adenine-nucleotide carrier. Eur J Biochem 106:1–6PubMedCrossRefGoogle Scholar
  4. Duyckaerts C, Sluse-Goffart CM, Sluse FE, Gosselin-Rey C, Liébecq C (1984) Spontaneous modification of the oxoglutarate translocator in vivo. Eur J Biochem 142:203–208PubMedCrossRefGoogle Scholar
  5. Evens A, Sluse-Goffart CM, Duyckaerts C, Camus G, Sluse FE (1988) Etude de la cinétique transitoire du transporteur adénylique. Abstr Congrès d’Automne de la Société de chimie biologique sur “Systèmes Bioénergétiques: Structure, contrôle et évolution” Bombannes FranceGoogle Scholar
  6. Sluse FE (1979) Alternating cooperativities in the kinetic and binding curves of the oxoglutarate translocator. Mathematical model. In: Quagliariello E, Palmieri F, Papa S, Klingenberg M (eds) Function and Molecular aspects of Biomembrane Transport. Elsevier, Amsterdam, pp 407–410Google Scholar
  7. Sluse FE, Meijer AJ, Tager JM (1971) Anion translocators in rat-heart mitochondria. FEBS Lett 18:149–153PubMedCrossRefGoogle Scholar
  8. Sluse FE, Ranson M, Liébecq C (1972) Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the exchange reactions between 2-oxoglutarate, malate and malonate. Eur J Biochem 25:207–217PubMedCrossRefGoogle Scholar
  9. Sluse FE, Goffart G, Liébecq C (1973a) Mechanism of the exchanges catalysed by the oxoglutarate translocator of rat-heart mitochondria. Kinetics of the external-product inhibition Eur J Biochem 32:283–291PubMedCrossRefGoogle Scholar
  10. Sluse FE, Liébecq C (1973b) Kinetics and mechanism of the exchange reactions catalysed by the oxoglutarate translocator of rat-heart mitochondria. Biochimie 55:747–754PubMedCrossRefGoogle Scholar
  11. Sluse FE, Sluse-Goffart CM, Duyckaerts C, Liébecq C (1975) Evidence for cooperative effects in the exchange reactions catalysed by the oxoglutarate translocator of rat-heart mitochondria. Eur J Biochem 56:1–14PubMedCrossRefGoogle Scholar
  12. Sluse FE, Duyckaerts C, Liébecq C, Sluse-Goffart CM (1979) Kinetic and binding properties of the oxoglutarate translocator of rat-heart mitochondria. Eur J Biochem 100:3–17PubMedCrossRefGoogle Scholar
  13. Sluse FE, Duyckaerts C, Sluse-Goffart CM, Fux JP, Liébecq C (1980) Oxoglutarate translocator of rat-heart mitochondria: regulation by aspartate. FEBS Lett 120:94–98PubMedCrossRefGoogle Scholar
  14. Sluse FE, Duyckaerts C, Bartolomé T, Sluse-Goffart CM, Liébecq C (1985) Regulation of the oxoglutarate translocator by adenine nucleotides. Abstr Special FEBS Meet on Metal Ions, Proteins and Membranes, Algarve, p 126Google Scholar
  15. Sluse FE, Duyckaerts C, Sluse-Goffart CM (1987a) Kinetics of adenine nucleotide translocator revisited. Abstr Journée sur le Contrôle du Métabolisme Cellulaire, Bordeaux, FranceGoogle Scholar
  16. Sluse FE, Sluse-Goffart CM (1987b) On kinetics of adenine nucleotide translocation. Lect on 9th Magdeburg Coll on “Mitochondrial Functions”, MagdeburgGoogle Scholar
  17. Sluse FE, Duyckaerts C, Sluse-Goffart CM (1988a) Kinetics of the adenine-nucleotide translocation in rat-heart mitochondria. Arch Int Physiol Biochim 96:B56Google Scholar
  18. Sluse FE, Duyckaerts C, Evens A, Sluse-Goffart CM (1988b) New attempt to determine the kinetic mechanism of the adenylic translocator: methodological prerequisite. Abstr Int Symp on Molecular Basis of Biomembrane Transport, Ostum, Italie, p 74Google Scholar
  19. Sluse-Goffart CM, Sluse FE, Duyckaerts C, Richard M, Hengesch P, Liébecq C (1983) Conformational changes and possible structure of the oxoglutarate translocator of rat-heart mitochondria revealed by the kinetic study of malate and oxoglutarate uptake. Eur J Biochem 134:397–406PubMedCrossRefGoogle Scholar
  20. Sluse-Goffart CM, Sluse FE (1986) Kinetics as a tool for the study of transmembrane exchanges exemplified by the study of the oxoglutarate translocator. In: Damjanovich S, Keleti T, Iron T (eds) Dynamics of Biochemical Systems. Elsevier, Amsterdam, pp 521–535Google Scholar
  21. Sluse-Goffart CM, Duyckaerts C, Bartholomé T, Sluse FE (1988) Study of the matricial face of the oxoglutarate translocator using inverted submitochondrial vesicles. Arch Int Physiol Biochim 96:B57Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1989

Authors and Affiliations

  • F. E. Sluse
    • 1
  • C. M. Sluse-Goffart
    • 1
  • C. Duyckaerts
    • 1
  1. 1.Unité de BioénergétiqueUniversité de Liège, Istitue Chimie (B-6) Sart-TilmanLiègeBelgium

Personalised recommendations