Immune Response to Oral Salmonella Vaccines

  • A. Tagliabue
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 146)

Abstract

Infections by Salmonella species still represent a public health problem throughout the world. Typhoid fever, the disease induced by S. typhi, remains one of the most common infections in developing countries, which may lead to death, particularly if associated with malnutrition. An incidence has been reported of 540 typhoid cases/100,000 (0.5%) inhabitants in the developing countries, with a total annual estimate of 12.5 million cases in the world (excluding China) (Edelman and Levine 1986). On the other hand, salmonellosis outbreaks caused by S. typhimurium, S. enteritidis, and other species are often observed in developed countries, sometimes as a consequence of modern habits in alimentation (kitchens catering for large numbers of people, microwave ovens, etc.). Thus, an effective and safe vaccine against Salmonellae is still considered a high priority by WHO in its Vaccine Development Programme.

Keywords

Microwave Acetone Polysaccharide Peri Egypt 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ashcroft MT, Singh B, Nicholson CC, Ritchie JM, Sobryan E, Williams F (1967) A seven year field trial of two typhoid vaccines in Guyana. Lancet ii:1056–1060CrossRefGoogle Scholar
  2. Chuttani CS, Prakash K, Vergese A, Sharma U, Singha P, Ray G (1971) Effectiveness of oral killed typhoid vaccine. Bull WHO 45:445–450PubMedGoogle Scholar
  3. Czerkinsky CC, Prince SJ, Michalek SM, Jackson S, Russell MW, Moldoveanu Z, McGhee JR, Mestecky J (1987) IgA antibody-producing cells in peripheral blood after antigen ingestion. Proc Natl Acad Sci USA 84:2449–2453PubMedCrossRefGoogle Scholar
  4. Edelman R, Levine MM (1986) Summary of an international workshop on typhoid fever. Rev Inf Dis 8:329–349CrossRefGoogle Scholar
  5. Forrest BD (1988) Identification of an intestinal immune response using peripheral blood lymphocytes. Lancet i:81–83CrossRefGoogle Scholar
  6. Germanier R, Furer E (1975) Isolation and characterization of gal E mutant Ty21a of Salmonella typhi: A candidate strain for a live oral typhoid vaccine. J Inf Dis 141:553–558CrossRefGoogle Scholar
  7. Heifec LB, Salmin LV, Lejtman MZ, Kuz’minova ML, Vasil’eva AV, Levina L, Bencianova TG, Pavlova EA, Antonova AA (1966) A controlled field trial and laboratory study of five typhoid vaccines in the USSR. Bull WHO 34:321–339Google Scholar
  8. Jirillo E, Caretto G, Grassi PP, Nencioni L, Tagliabue A (1988) Antibody-driven T cell-mediated activity against enteropathogenic bacteria: A comparison between human volunteers from endemic and non-endemic areas for typhoid fever. (Submitted for publication)Google Scholar
  9. Klugman KP, Gilbertson IT, Koornhof HJ, Schneerson R, Cadoz M, Gilbertson IT, Robbins JB, Schultz D, Armand J, Vaccination Advisory Committee (1987) Protective activity of Vi capsular polysaccharide vaccine against typhoid fever. Lancet i:1165–1169CrossRefGoogle Scholar
  10. Kumar R, Malaviya AN, Murthy RGS, Venkataraman M, Mohapatra LN (1974) Immunological study of typhoid: Immunoglobulins, C3, antibodies, and leukocyte migration-inhibition in patients with typhoid fever and TAB-vaccinated individuals. Infect Immun 10:1219–1225PubMedGoogle Scholar
  11. Levine MM, Ferreccio C, Black RE, Germanier R, Chilean Typhoid Committee (1987a) Large-scale field trial of Ty21a live oral typhoid vaccine in enteric-coated capsule formation. Lancet i:1049–1052CrossRefGoogle Scholar
  12. Levine MM, Herrington D, Murphy JR, Morris JG, Losonsky G, Tall B, Lindberg AA, Svenson S, Bayar S, Edwards MF, Stocken B (1987b) Safety, infectivity, immunogenicity and in vivo stability of two attenuated auxotrophic mutant strains of Salmonella typhi, 541 Ty and 543 Ty, as live oral vaccines in humans. J Clin Invest 79:888–902PubMedCrossRefGoogle Scholar
  13. Morris-Hooke A, Wang Z, Cerquetti MC, Bellanti JA (1986) Temperature-sensitive vaccine strains of Salmonella typhi. In: Tagliabue A, Rappuoli R, Piazzi SE (eds) Bacterial Vaccines and Local Immunity. Ann Sclavo 1–2, p 23Google Scholar
  14. Murphy JR, Bagar S, Munoz C, Schlesinger L, Ferreccio C, Lindberg AA, Svenson S, Losonsky G, Koster F, Levine MM (1987) Characteristics of humoral and cellular immunity to Salmonella typhi in residents of typhoid-endemic and typhoid-free regions. J Inf Dis 156:1005–1009CrossRefGoogle Scholar
  15. Nencioni L, Villa L, Boraschi D, Berti B, Tagliabue A (1983) Natural and antibody-dependent cell-mediated activity against Salmonella typhimurium by peripheral and intestinal lymphoid cells in mice. J Immunol 130:903–907PubMedGoogle Scholar
  16. Tagliabue A, Boraschi D, Villa L, Keren DF, Lowell GH, Rappuoli R, Nencioni L (1984) IgA-dependent cell-mediated acitivity against enteropathogenic bacteria: Distribution, specificity and characterization of the effector cells. J Immunol 133:988–992PubMedGoogle Scholar
  17. Tagliabue A, Nencioni L, Caffarena A, Villa L, Boraschi D, Cazzola G, Cavalieri S (1985a) Cellular immunity against Salmonella typhi after live oral vaccine. Clin Exp Immunol 62:242–247PubMedGoogle Scholar
  18. Tagliabue A, Nencioni L, Mantovani M, Lazzarin A, Villa L, Romano M, Rossini S, Uberti-Foppa C, Fanetti G, Masello LC, Poli G (1988) Improvement of in vitro natural antibacterial activity in HIV infected patients (Submitted for publication)Google Scholar
  19. Tagliabue A, Nencioni L, Villa L, Keren DF, Lowell GH, Boraschi D (1983) Antibody-dependent cell-mediated antibacterial activity of intestinal lymphocytes with secretory IgA. Nature 306:184–186PubMedCrossRefGoogle Scholar
  20. Tagliabue A, Villa L, Boraschi D, Peri G, De Gori V, Nencioni L (1985b) Natural antibacterial activity against Salmonella typhi by human T4+ lymphocytes armed with IgA antibodies. J Immunol 135:4178–4182PubMedGoogle Scholar
  21. Tagliabue A, Villa L, De Magistris MT, Romano M, Silvestri S, Boraschi D, Nencioni L (1986) IgA-driven T cell-mediated antibacterial immunity in man after live oral Ty21a vaccine. J Immunol 137:1504–1510PubMedGoogle Scholar
  22. Wahdan MJ, Serie C, Cerisier Y, Sallam S, Germanier R (1982) A controlled field trial of live Salmonella typhi strain Ty21a oral vaccine against typhoid: Three year results. J Inf Dis 145:292–296CrossRefGoogle Scholar
  23. Weber J (1986) Gastrointestinal disease in AIDS. Clin Immunol Allergy 6:519–541Google Scholar
  24. Yugoslav Typhoid Commission (1964) A controlled field trial of the effectiveness of acetone-dried and inactivated and heat-phenolinactivated typhoid vaccines in Yugoslavia. Bull WHO 30:623–630Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • A. Tagliabue
    • 1
  1. 1.Sclavo Research CenterSienaItaly

Personalised recommendations