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Oral Immunization Against Cholera

  • J. Holmgren
  • J. Clemens
  • D. A. Sack
  • J. Sanchez
  • A.-M. Svennerholm
Part of the Current Topics in Microbiology and Immunology book series (CT MICROBIOLOGY, volume 146)

Abstract

Cholera is an important cause of morbidity and mortality in many developing countries. Convalescents from this disease develop a substantial but not complete immunity against new attacks of cholera (Glass et al. 1982). Although cholera can be effectively treated by oral and/or intravenous rehydration, development of a vaccine that is capable of preventing cases and reducing the severity of cholera would provide the best immediate possibility to control the disease. If this vaccine could also provide protection against diarrhea caused by heat-labile enterotoxin (LT)-producing Escherichia coli its importance as a preventive health measure would be even more significant (Holmgren and Svennerholm 1985).

Keywords

Cholera Toxin Protective Efficacy Oral Immunization Cholerae Strain Cholera Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1989

Authors and Affiliations

  • J. Holmgren
    • 1
  • J. Clemens
    • 2
  • D. A. Sack
    • 2
  • J. Sanchez
    • 1
  • A.-M. Svennerholm
    • 1
  1. 1.Department of Medical MicrobiologyUniversity of GöteborgGöteborgSweden
  2. 2.International Centre for Diarrhoeal Disease ResearchBangladeshBangladesh

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