Oral Immunization Against Cholera
Cholera is an important cause of morbidity and mortality in many developing countries. Convalescents from this disease develop a substantial but not complete immunity against new attacks of cholera (Glass et al. 1982). Although cholera can be effectively treated by oral and/or intravenous rehydration, development of a vaccine that is capable of preventing cases and reducing the severity of cholera would provide the best immediate possibility to control the disease. If this vaccine could also provide protection against diarrhea caused by heat-labile enterotoxin (LT)-producing Escherichia coli its importance as a preventive health measure would be even more significant (Holmgren and Svennerholm 1985).
KeywordsPlacebo Formalin Toxicity Filtration Carboxyl
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